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Mesoscale conformational changes in the DNA-repair complex Rad50/Mre11/Nbs1 upon binding DNA

Author

Listed:
  • Fernando Moreno-Herrero

    (Delft University of Technology)

  • Martijn de Jager

    (Department of Cell Biology and Genetics)

  • Nynke H. Dekker

    (Delft University of Technology)

  • Roland Kanaar

    (Department of Cell Biology and Genetics
    Erasmus MC)

  • Claire Wyman

    (Department of Cell Biology and Genetics
    Erasmus MC)

  • Cees Dekker

    (Delft University of Technology)

Abstract

Atherosclerosis induction Atherosclerotic plaques form when blood flow is disturbed and unusual patterns of mechanical stress are applied to the blood vessel wall. The endothelial cells lining these vessels play an important role in the development of the disease. A study using cultured aortic endothelial cells now shows that three proteins expressed in endothelial cells form a mechanosensory complex, and each one has distinct functions in transducing mechanical force into a biochemical signal inside the cell. This can explain how blood flow stimulates endothelial cell responses and how atherosclerotic plaques might be initiated.

Suggested Citation

  • Fernando Moreno-Herrero & Martijn de Jager & Nynke H. Dekker & Roland Kanaar & Claire Wyman & Cees Dekker, 2005. "Mesoscale conformational changes in the DNA-repair complex Rad50/Mre11/Nbs1 upon binding DNA," Nature, Nature, vol. 437(7057), pages 440-443, September.
    • Handle: RePEc:nat:nature:v:437:y:2005:i:7057:d:10.1038_nature03927
    DOI: 10.1038/nature03927
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