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A mechanistic principle for proton pumping by cytochrome c oxidase

Author

Listed:
  • Kristina Faxén

    (Stockholm University)

  • Gwen Gilderson

    (Stockholm University)

  • Pia Ädelroth

    (Stockholm University)

  • Peter Brzezinski

    (Stockholm University)

Abstract

Pump it up The nature of proton pumping by cytochrome c oxidase, last link in the electron transfer chain in mitochondria and many bacteria, has been a reliable source of controversy over the years. Its mechanism of action is still something of a mystery, but a new study of proton pumping events in lipid vesicles containing a single molecule of the oxidase suggests a mechanism of action that could be generalized to all membrane-bound ion transporters.

Suggested Citation

  • Kristina Faxén & Gwen Gilderson & Pia Ädelroth & Peter Brzezinski, 2005. "A mechanistic principle for proton pumping by cytochrome c oxidase," Nature, Nature, vol. 437(7056), pages 286-289, September.
    • Handle: RePEc:nat:nature:v:437:y:2005:i:7056:d:10.1038_nature03921
    DOI: 10.1038/nature03921
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