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Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development

Author

Listed:
  • Abdolrahman S. Nateri

    (Mammalian Genetics Laboratory)

  • Bradley Spencer-Dene

    (Lincoln's Inn Fields Laboratories
    Imperial College)

  • Axel Behrens

    (Mammalian Genetics Laboratory)

Abstract

Bowel cancer: JNK bonds A previously unknown link between the molecular pathways involving the transcription factors c-Jun and TCF4 may be important in bowel cancer development. Phosphorylated c-Jun interacts with TCF4 to form a complex that regulates gene promoters responsive to both WNT and JNK signalling. Blocking this interaction in the ApcMin mouse model of intestinal cancer delays tumorigenesis and reduces the number and size of tumours produced. It is particularly interesting that JNK may be a promising strategy to treat colon cancer, as small- molecule JNK inhibitors are already in clinical trials.

Suggested Citation

  • Abdolrahman S. Nateri & Bradley Spencer-Dene & Axel Behrens, 2005. "Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development," Nature, Nature, vol. 437(7056), pages 281-285, September.
    • Handle: RePEc:nat:nature:v:437:y:2005:i:7056:d:10.1038_nature03914
    DOI: 10.1038/nature03914
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    Cited by:

    1. Christopher A. Waudby & Saul Alvarez-Teijeiro & E. Josue Ruiz & Simon Suppinger & Nikos Pinotsis & Paul R. Brown & Axel Behrens & John Christodoulou & Anastasia Mylona, 2022. "An intrinsic temporal order of c-JUN N-terminal phosphorylation regulates its activity by orchestrating co-factor recruitment," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

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