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Sporadic immunogenic tumours avoid destruction by inducing T-cell tolerance

Author

Listed:
  • Gerald Willimsky

    (Charité Campus Benjamin Franklin)

  • Thomas Blankenstein

    (Charité Campus Benjamin Franklin
    Max Delbrück Center for Molecular Medicine)

Abstract

Duping the T cell Cancer immunosurveillance, the spontaneous recognition and elimination of tumours by T cells, is known to control certain virus-associated tumours but its role in the control of spontaneous tumours is a matter of some controversy. If immunosurveillance is involved, any immunogenic tumours that do eventually grow are likely to be escape variants, selected for low immunogenicity by T cells. A new transgenic mouse model in which sporadic tumours derive from a single cell and express a defined tumour-specific rejection antigen makes it possible to analyse the spontaneous immune response against tumours that develop slowly from single cells, thus reflecting physiological tumour development as closely as possible. Experiments on these mice suggest that there is no immunosurveillance: sporadic immunogenic tumours escape destruction by inducing T-cell tolerance, not by losing their intrinsic immunogenicity.

Suggested Citation

  • Gerald Willimsky & Thomas Blankenstein, 2005. "Sporadic immunogenic tumours avoid destruction by inducing T-cell tolerance," Nature, Nature, vol. 437(7055), pages 141-146, September.
    • Handle: RePEc:nat:nature:v:437:y:2005:i:7055:d:10.1038_nature03954
    DOI: 10.1038/nature03954
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