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Mechanism of action of interferon and ribavirin in treatment of hepatitis C

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  • Jordan J. Feld

    (Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases)

  • Jay H. Hoofnagle

    (National Institutes of Health)

Abstract

Since the identification of the hepatitis C virus, great strides have been made in the development of an antiviral therapy. As a crucial mediator of the innate antiviral immune response, interferon-α (IFN-α) was a natural choice for treatment. Whereas treatment with IFN-α alone achieved only modest success, the addition of the broad-spectrum antiviral agent ribavirin greatly improved responses. However, half of the infected individuals with chronic disease do not achieve sustained clearance of hepatitis C virus. To optimize current therapeutic strategies and to develop new therapies, a better understanding of the mechanism of action of IFN and ribavirin will be essential.

Suggested Citation

  • Jordan J. Feld & Jay H. Hoofnagle, 2005. "Mechanism of action of interferon and ribavirin in treatment of hepatitis C," Nature, Nature, vol. 436(7053), pages 967-972, August.
    • Handle: RePEc:nat:nature:v:436:y:2005:i:7053:d:10.1038_nature04082
    DOI: 10.1038/nature04082
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