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Challenges and successes in developing new therapies for hepatitis C

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  • Raffaele De Francesco

    (Istituto di Ricerche di Biologia Molecolare P. Angeletti)

  • Giovanni Migliaccio

    (Istituto di Ricerche di Biologia Molecolare P. Angeletti)

Abstract

Hepatitis C virus (HCV) will continue to be a serious global health threat for many years to come because of the chronic nature of the infection, its high prevalence and the significant morbidity of the resulting disease. Recently, a small number of molecules have produced encouraging results in proof-of-concept clinical trials. At the same time, preclinical evidence is accumulating that development of resistance will eventually limit the efficacy of new drugs. Thus, combinations of multiple agents will be required to treat chronic HCV infection.

Suggested Citation

  • Raffaele De Francesco & Giovanni Migliaccio, 2005. "Challenges and successes in developing new therapies for hepatitis C," Nature, Nature, vol. 436(7053), pages 953-960, August.
    • Handle: RePEc:nat:nature:v:436:y:2005:i:7053:d:10.1038_nature04080
    DOI: 10.1038/nature04080
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