IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v436y2005i7053d10.1038_nature04078.html
   My bibliography  Save this article

Evasion of intracellular host defence by hepatitis C virus

Author

Listed:
  • Michael Gale

    (University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard)

  • Eileen M. Foy

    (University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard)

Abstract

Viral infection of mammalian cells rapidly triggers intracellular signalling events leading to interferon α/β production and a cellular antiviral state. This ‘host response’ is our first line of immune defence against infection as it imposes several barriers to viral replication and spread. Hepatitis C virus (HCV) evades the host response through a complex combination of processes that include signalling interference, effector modulation and continual viral genetic variation. These evasion strategies support persistent infection and the spread of HCV. Defining the molecular mechanisms by which HCV regulates the host response is of crucial importance and may reveal targets for novel therapeutic strategies.

Suggested Citation

  • Michael Gale & Eileen M. Foy, 2005. "Evasion of intracellular host defence by hepatitis C virus," Nature, Nature, vol. 436(7053), pages 939-945, August.
    • Handle: RePEc:nat:nature:v:436:y:2005:i:7053:d:10.1038_nature04078
    DOI: 10.1038/nature04078
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature04078
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature04078?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:436:y:2005:i:7053:d:10.1038_nature04078. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.