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The hangover gene defines a stress pathway required for ethanol tolerance development

Author

Listed:
  • Henrike Scholz

    (Department of Anatomy
    Biozentrum, University of Würzburg)

  • Mirjam Franz

    (Biozentrum, University of Würzburg)

  • Ulrike Heberlein

    (Department of Anatomy
    University of California at San Francisco)

Abstract

Genetics of alcohol tolerance Improbable as it may seem, Drosophila fruit flies can be used as a model for alcohol-induced behaviours. Exposed to ethanol vapour in a device known as an inebriometer (it looks like a glass condenser), they lose control of their posture and sink to the bottom of the tube within 20 minutes. Repeated alcohol consumption leads to tolerance, but not in flies with a newly identified mutation. Flies with this hangover mutation also have a shortened life span and are more susceptible to stresses such as heat and insecticides. There is growing recognition that cellular and systemic stress contributes to drug- and addiction-related behaviours in mammals, and these studies suggest that this role may be conserved in evolution.

Suggested Citation

  • Henrike Scholz & Mirjam Franz & Ulrike Heberlein, 2005. "The hangover gene defines a stress pathway required for ethanol tolerance development," Nature, Nature, vol. 436(7052), pages 845-847, August.
    • Handle: RePEc:nat:nature:v:436:y:2005:i:7052:d:10.1038_nature03864
    DOI: 10.1038/nature03864
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    Cited by:

    1. Philippa Mitchell & Richard Mould & James Dillon & Steven Glautier & Ioannis Andrianakis & Christopher James & Amanda Pugh & Lindy Holden-Dye & Vincent O'Connor, 2010. "A Differential Role for Neuropeptides in Acute and Chronic Adaptive Responses to Alcohol: Behavioural and Genetic Analysis in Caenorhabditis elegans," PLOS ONE, Public Library of Science, vol. 5(5), pages 1-17, May.

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