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Male-specific fruitless specifies the neural substrates of Drosophila courtship behaviour

Author

Listed:
  • Devanand S. Manoli

    (Neurosciences Program
    Stanford University)

  • Margit Foss

    (Oregon State University)

  • Adriana Villella

    (Brandeis University)

  • Barbara J. Taylor

    (Oregon State University)

  • Jeffrey C. Hall

    (Brandeis University)

  • Bruce S. Baker

    (Stanford University)

Abstract

Courtship in the genes During courtship, male Drosophila fruitflies perform a series of innate stereotyped behaviours in response to specific sensory cues. Now the set of nerve cells that govern this behaviour has been identified. Inactivation of these neurons is sufficient to make male flies lose interest in mating, and altering female brains to produce the same proteins produced by these cells causes the females to display male courtship routines. The neurons produce a set of proteins called FruM, encoded by the fruitless (fru) gene, which has previously been implicated in courtship in male fruitflies. Inactivation of FruM-producing nerve cells inhibited courtship without changing other behaviours. And manipulating females' nerve cells so as to produce FruM was enough to cause them to view other females as potential mates.

Suggested Citation

  • Devanand S. Manoli & Margit Foss & Adriana Villella & Barbara J. Taylor & Jeffrey C. Hall & Bruce S. Baker, 2005. "Male-specific fruitless specifies the neural substrates of Drosophila courtship behaviour," Nature, Nature, vol. 436(7049), pages 395-400, July.
    • Handle: RePEc:nat:nature:v:436:y:2005:i:7049:d:10.1038_nature03859
    DOI: 10.1038/nature03859
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