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Regulation of Mycobacterium tuberculosis cell envelope composition and virulence by intramembrane proteolysis

Author

Listed:
  • Hideki Makinoshima

    (Sloan-Kettering Institute)

  • Michael S. Glickman

    (Sloan-Kettering Institute
    Memorial Sloan-Kettering Cancer Center)

Abstract

Tuberculosis target Many of the virulence determinants of Mycobacterium tuberculosis are lipids and glycolipids of the cell envelope. Now at last a mechanism that controls cell envelope composition — and in vivo pathogenesis — has been uncovered. It is regulated intramembrane proteolysis, a type of lipid regulation also used by mammals and bacteria. RIP may be an attractive pathway to target for development of new antituberculosis antibiotics.

Suggested Citation

  • Hideki Makinoshima & Michael S. Glickman, 2005. "Regulation of Mycobacterium tuberculosis cell envelope composition and virulence by intramembrane proteolysis," Nature, Nature, vol. 436(7049), pages 406-409, July.
    • Handle: RePEc:nat:nature:v:436:y:2005:i:7049:d:10.1038_nature03713
    DOI: 10.1038/nature03713
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