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Cancer gene discovery in solid tumours using transposon-based somatic mutagenesis in the mouse

Author

Listed:
  • Lara S. Collier

    (The University of Minnesota Twin Cities)

  • Corey M. Carlson

    (The University of Minnesota Twin Cities)

  • Shruthi Ravimohan

    (The University of Minnesota Twin Cities
    The Johns Hopkins School of Medicine)

  • Adam J. Dupuy

    (The University of Minnesota Twin Cities
    National Cancer Institute)

  • David A. Largaespada

    (The University of Minnesota Twin Cities)

Abstract

Solid tumour screening Two papers this week report the use of a potent new mammalian genetic tool for understanding solid tumour formation. Until now forward genetic screening for cancer genes has been possible only in the haematopoietic system or mammary gland, using murine leukaemia viruses or mammary tumour viruses. The new method extends forward screening to solid tumours using the Sleeping Beauty transposon (jumping gene). If Sleeping Beauty slots into a chromosome near a potential cancer gene, tumour formation occurs and the gene can be identified.

Suggested Citation

  • Lara S. Collier & Corey M. Carlson & Shruthi Ravimohan & Adam J. Dupuy & David A. Largaespada, 2005. "Cancer gene discovery in solid tumours using transposon-based somatic mutagenesis in the mouse," Nature, Nature, vol. 436(7048), pages 272-276, July.
    • Handle: RePEc:nat:nature:v:436:y:2005:i:7048:d:10.1038_nature03681
    DOI: 10.1038/nature03681
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