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A microRNA polycistron as a potential human oncogene

Author

Listed:
  • Lin He

    (Watson School of Biological Sciences)

  • J. Michael Thomson

    (University of North Carolina)

  • Michael T. Hemann

    (Watson School of Biological Sciences)

  • Eva Hernando-Monge

    (Memorial Sloan-Kettering Cancer Center)

  • David Mu

    (Watson School of Biological Sciences)

  • Summer Goodson

    (University of North Carolina)

  • Scott Powers

    (Watson School of Biological Sciences)

  • Carlos Cordon-Cardo

    (Memorial Sloan-Kettering Cancer Center)

  • Scott W. Lowe

    (Watson School of Biological Sciences)

  • Gregory J. Hannon

    (Watson School of Biological Sciences)

  • Scott M. Hammond

    (University of North Carolina
    University of North Carolina)

Abstract

MicroRNA in cancer MicroRNAs are regulatory, non-coding RNAs about 22 nucleotides in length: over 200 have been identified in humans, and their functions are beginning to be pinned down. It has been suggested that like other regulatory molecules they might be involved in tumour formation, and three papers in this issue confirm that this is the case. One cluster of microRNAs, known as mir-17–92, is shown to be a potential oncogene by its action in an in vivo model of human B-cell lymphoma. A cluster of microRNAs on human chromosome 13 has been found to be regulated by c-Myc, an important transcription factor that is overexpressed in many human cancers. And analysis of microRNA expression in over 300 individuals shows that microRNA profiles could be of value in cancer diagnosis. There is a global downregulation of microRNA in tumours, and the microRNA profile also reflects the origin and differentiation state of the tumours.

Suggested Citation

  • Lin He & J. Michael Thomson & Michael T. Hemann & Eva Hernando-Monge & David Mu & Summer Goodson & Scott Powers & Carlos Cordon-Cardo & Scott W. Lowe & Gregory J. Hannon & Scott M. Hammond, 2005. "A microRNA polycistron as a potential human oncogene," Nature, Nature, vol. 435(7043), pages 828-833, June.
    • Handle: RePEc:nat:nature:v:435:y:2005:i:7043:d:10.1038_nature03552
    DOI: 10.1038/nature03552
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