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Regulation of immunity by self-reactive T cells

Author

Listed:
  • Mitchell Kronenberg

    (La Jolla Institute for Allergy and Immunology)

  • Alexander Rudensky

    (Howard Hughes Medical Institute and Department of Immunology
    University of Washington)

Abstract

A basic principle of immunology is that lymphocytes respond to foreign antigens but tolerate self tissues. For developing T cells, the ability to distinguish self from non-self is acquired in the thymus, where the majority of self-reactive cells are eliminated. Recently, however, it has become apparent that some self-reactive T cells avoid being destroyed and instead differentiate into specialized regulatory cells. This appears to be beneficial. Subpopulations of self-reactive T cells have a strong influence on self tolerance and may represent targets for therapeutic intervention to control a variety of autoimmune diseases, tumour growth and infection.

Suggested Citation

  • Mitchell Kronenberg & Alexander Rudensky, 2005. "Regulation of immunity by self-reactive T cells," Nature, Nature, vol. 435(7042), pages 598-604, June.
    • Handle: RePEc:nat:nature:v:435:y:2005:i:7042:d:10.1038_nature03725
    DOI: 10.1038/nature03725
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