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Cellular and genetic mechanisms of self tolerance and autoimmunity

Author

Listed:
  • Christopher C. Goodnow

    (John Curtin School of Medical Research
    Australian Phenomics Facility, The Australian National University)

  • Jonathon Sprent

    (IMM4, The Scripps Research Institute)

  • Barbara Fazekas de St Groth

    (Centenary Institute of Cancer Medicine and Cell Biology)

  • Carola G. Vinuesa

    (John Curtin School of Medical Research)

Abstract

The mammalian immune system has an extraordinary potential for making receptors that sense and neutralize any chemical entity entering the body. Inevitably, some of these receptors recognize components of our own body, and so cellular mechanisms have evolved to control the activity of these ‘forbidden’ receptors and achieve immunological self tolerance. Many of the genes and proteins involved are conserved between humans and other mammals. This provides the bridge between clinical studies and mechanisms defined in experimental animals to understand how sets of gene products coordinate self-tolerance mechanisms and how defects in these controls lead to autoimmune disease.

Suggested Citation

  • Christopher C. Goodnow & Jonathon Sprent & Barbara Fazekas de St Groth & Carola G. Vinuesa, 2005. "Cellular and genetic mechanisms of self tolerance and autoimmunity," Nature, Nature, vol. 435(7042), pages 590-597, June.
    • Handle: RePEc:nat:nature:v:435:y:2005:i:7042:d:10.1038_nature03724
    DOI: 10.1038/nature03724
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