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SV40-encoded microRNAs regulate viral gene expression and reduce susceptibility to cytotoxic T cells

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  • Christopher S. Sullivan

    (University of California)

  • Adam T. Grundhoff

    (University of California)

  • Satvir Tevethia

    (The Pennsylvania State College of Medicine)

  • James M. Pipas

    (University of Pittsburgh)

  • Don Ganem

    (University of California)

Abstract

Viral microRNAs MicroRNAs are a large class of noncoding small RNAs, about 22 nucleotides in length, thought to target other genes and regulate their expression. Their regulatory role has been demonstrated in lower organisms: microRNAs are present in mammals including humans, though their role in higher organisms is not clear. Now they have been found to have a function in virus biology. SV40 virus encodes several microRNAs involved in the late stages of infection of monkey cells. These microRNAs maintain viral replicative efficiency by reducing excess antigen production. It has been suggested that inhibitory RNA systems in mammals are there as a defence against viruses, suggesting that what is normally an antiviral defence pathway is being subverted by the virus for its own purposes.

Suggested Citation

  • Christopher S. Sullivan & Adam T. Grundhoff & Satvir Tevethia & James M. Pipas & Don Ganem, 2005. "SV40-encoded microRNAs regulate viral gene expression and reduce susceptibility to cytotoxic T cells," Nature, Nature, vol. 435(7042), pages 682-686, June.
    • Handle: RePEc:nat:nature:v:435:y:2005:i:7042:d:10.1038_nature03576
    DOI: 10.1038/nature03576
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    Cited by:

    1. Noreen Ahmed & Nadine Ahmed & Didier A. Bilodeau & John Paul Pezacki, 2023. "An unnatural enzyme with endonuclease activity towards small non-coding RNAs," Nature Communications, Nature, vol. 14(1), pages 1-12, December.

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