IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v435y2005i7039d10.1038_nature03625.html
   My bibliography  Save this article

Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope

Author

Listed:
  • Sally C. Kent

    (Brigham and Women's Hospital and Harvard Medical School)

  • Yahua Chen

    (Brigham and Women's Hospital and Harvard Medical School)

  • Lisa Bregoli

    (Brigham and Women's Hospital and Harvard Medical School)

  • Sue M. Clemmings

    (University of Minnesota)

  • Norma Sue Kenyon

    (University of Miami)

  • Camillo Ricordi

    (University of Miami)

  • Bernhard J. Hering

    (University of Minnesota)

  • David A. Hafler

    (Brigham and Women's Hospital and Harvard Medical School)

Abstract

Insulin sparks autoimmunity Autoimmune reactions, in which the body's white blood cells harm its own tissues, cause many diseases including diabetes, multiple sclerosis and arthritis. It is not known why immune cells target certain organs, and in particular for childhood diabetes, why only insulin-producing cells are killed. Nakayama et al. now report that this may be because insulin itself is a primary autoantigen for autoimmune diabetes. In NOD mice, the standard animal model for diabetes, when the part of the insulin molecule that gives rise to autoantibodies is altered, autoimmune diabetes disappears. This also suggests that deletional immune therapy could be a practical proposition. The possible clinical relevance of this work is confirmed by a separate study by Kent et al. of human patients with type 1 diabetes. T lymphocytes found in the draining lymph nodes around the pancreas specifically recognize part of the insulin protein. This has implications for antigen specific therapies and islet-cell transplantation in diabetes.

Suggested Citation

  • Sally C. Kent & Yahua Chen & Lisa Bregoli & Sue M. Clemmings & Norma Sue Kenyon & Camillo Ricordi & Bernhard J. Hering & David A. Hafler, 2005. "Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope," Nature, Nature, vol. 435(7039), pages 224-228, May.
    • Handle: RePEc:nat:nature:v:435:y:2005:i:7039:d:10.1038_nature03625
    DOI: 10.1038/nature03625
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature03625
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature03625?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:435:y:2005:i:7039:d:10.1038_nature03625. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.