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LPA3-mediated lysophosphatidic acid signalling in embryo implantation and spacing

Author

Listed:
  • Xiaoqin Ye

    (The Scripps Research Institute)

  • Kotaro Hama

    (University of Tokyo)

  • James J. A. Contos

    (Fred Hutchinson Cancer Research Center)

  • Brigitte Anliker

    (The Scripps Research Institute)

  • Asuka Inoue

    (University of Tokyo)

  • Michael K. Skinner

    (Washington State University)

  • Hiroshi Suzuki

    (University of Tokyo
    Obihiro University of Agriculture and Veterinary Medicine)

  • Tomokazu Amano

    (University of Tokyo)

  • Grace Kennedy

    (The Scripps Research Institute)

  • Hiroyuki Arai

    (University of Tokyo)

  • Junken Aoki

    (University of Tokyo)

  • Jerold Chun

    (The Scripps Research Institute)

Abstract

Embryo implantation The molecular mechanisms affecting female reproduction, particularly therapeutically tractable ones, are incompletely understood. So the identification of a new signalling mechanism affecting fertility via embryo implantation could be important. The compound involved is lysophosphatidic acid (LPA), acting through a G protein-coupled receptor. Targeted deletion of the receptor, called LPA3, produces mice that display delayed implantation, altered implantation spacing, hypertrophic placentas and embryonic death. G protein-coupled receptors are among the most common targets of drug action, raising the possibility of developing new medicines for the treatment of infertility by targeting the LPA3 receptor.

Suggested Citation

  • Xiaoqin Ye & Kotaro Hama & James J. A. Contos & Brigitte Anliker & Asuka Inoue & Michael K. Skinner & Hiroshi Suzuki & Tomokazu Amano & Grace Kennedy & Hiroyuki Arai & Junken Aoki & Jerold Chun, 2005. "LPA3-mediated lysophosphatidic acid signalling in embryo implantation and spacing," Nature, Nature, vol. 435(7038), pages 104-108, May.
    • Handle: RePEc:nat:nature:v:435:y:2005:i:7038:d:10.1038_nature03505
    DOI: 10.1038/nature03505
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