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Hypothalamic KATP channels control hepatic glucose production

Author

Listed:
  • Alessandro Pocai

    (Albert Einstein College of Medicine)

  • Tony K. T. Lam

    (Albert Einstein College of Medicine)

  • Roger Gutierrez-Juarez

    (Albert Einstein College of Medicine)

  • Silvana Obici

    (Albert Einstein College of Medicine)

  • Gary J. Schwartz

    (Albert Einstein College of Medicine)

  • Joseph Bryan

    (Baylor College of Medicine)

  • Lydia Aguilar-Bryan

    (Baylor College of Medicine)

  • Luciano Rossetti

    (Albert Einstein College of Medicine)

Abstract

Neural development The wiring of neural circuits is modulated by early neural activity in the developing network of axons, and an understanding of the mechanism involved is one of the central questions in neurobiology. Past research addressing this question has focused on the patterning of axon bundles, but now combined genetic and state-of-the-art imaging tools make it possible to follow axon growth of individual neurons in live animals. The observations show that activity-dependent competition between axons regulates axon growth even before any connection has been made. So axon competition acts upon axon branch formation, not just on branch stability as is commonly believed, a finding that broadens the range of potential signalling pathways contributing to neural development.

Suggested Citation

  • Alessandro Pocai & Tony K. T. Lam & Roger Gutierrez-Juarez & Silvana Obici & Gary J. Schwartz & Joseph Bryan & Lydia Aguilar-Bryan & Luciano Rossetti, 2005. "Hypothalamic KATP channels control hepatic glucose production," Nature, Nature, vol. 434(7036), pages 1026-1031, April.
    • Handle: RePEc:nat:nature:v:434:y:2005:i:7036:d:10.1038_nature03439
    DOI: 10.1038/nature03439
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