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The MET oncogene drives a genetic programme linking cancer to haemostasis

Author

Listed:
  • Carla Boccaccio

    (University of Turin Medical School)

  • Gabriella Sabatino

    (University of Turin Medical School)

  • Enzo Medico

    (University of Turin Medical School)

  • Flavia Girolami

    (University of Turin Medical School)

  • Antonia Follenzi

    (University of Turin Medical School)

  • Gigliola Reato

    (University of Turin Medical School)

  • Antonino Sottile

    (University of Turin Medical School)

  • Luigi Naldini

    (University of Turin Medical School)

  • Paolo M. Comoglio

    (University of Turin Medical School)

Abstract

Blood clotting and cancer Since migratory thrombophlebitis was noted by Trousseau during diagnosis of his own pancreatic cancer in 1865, blood clotting disorders have been regularly reported as a sign of occult (as in without readily detectable symptoms) malignancies. No direct link between tumorigenesis and blood clotting had been found, until now. In a mouse model for liver cancer, the human oncogene MET that triggers tumour development is shown to regulate genes responsible for haemostasis. Mice in which MET is active develop venous thromboses similar to those seen in human occult malignancies and overt cancers.

Suggested Citation

  • Carla Boccaccio & Gabriella Sabatino & Enzo Medico & Flavia Girolami & Antonia Follenzi & Gigliola Reato & Antonino Sottile & Luigi Naldini & Paolo M. Comoglio, 2005. "The MET oncogene drives a genetic programme linking cancer to haemostasis," Nature, Nature, vol. 434(7031), pages 396-400, March.
    • Handle: RePEc:nat:nature:v:434:y:2005:i:7031:d:10.1038_nature03357
    DOI: 10.1038/nature03357
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