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An anaerobic mitochondrion that produces hydrogen

Author

Listed:
  • Brigitte Boxma

    (Radboud University Nijmegen)

  • Rob M. de Graaf

    (Radboud University Nijmegen)

  • Georg W. M. van der Staay

    (Radboud University Nijmegen)

  • Theo A. van Alen

    (Radboud University Nijmegen)

  • Guenola Ricard

    (Centre for Molecular and Biomolecular Informatics)

  • Toni Gabaldón

    (Centre for Molecular and Biomolecular Informatics)

  • Angela H. A. M. van Hoek

    (Radboud University Nijmegen
    RIKILT, Institute of Food Safety)

  • Seung Yeo Moon-van der Staay

    (Radboud University Nijmegen)

  • Werner J. H. Koopman

    (Nijmegen Centre of Molecular Life Sciences (NCMLS), Radboud University Nijmegen Medical Centre)

  • Jaap J. van Hellemond

    (Utrecht University)

  • Aloysius G. M. Tielens

    (Utrecht University)

  • Thorsten Friedrich

    (Institut für Organische Chemie und Biochemie)

  • Marten Veenhuis

    (Groningen University)

  • Martijn A. Huynen

    (Centre for Molecular and Biomolecular Informatics)

  • Johannes H. P. Hackstein

    (Radboud University Nijmegen)

Abstract

Change in the air Hydrogenosomes are simple organelles found in anaerobic protists and fungi. They are double-membraned and produce ATP and hydrogen, hence suggestions that they are anaerobic derivatives of mitochondria. An alternative view suggests that mitochondria and hydrogenosomes arose from a common ancestor, a facultatively anaerobic bacterium. The discovery of a novel hydrogenosome in Nyctotherus ovalis, a ciliate that lives in the gut of cockroaches, further complicates this debate. It is unique among known hydrogenosomes because, just like a mitochondrion, it retains its own genome. This ‘missing link’ between hydrogenosomes and mitochondria also has remnants of an electron transport chain characteristic of an aerobic lifestyle.

Suggested Citation

  • Brigitte Boxma & Rob M. de Graaf & Georg W. M. van der Staay & Theo A. van Alen & Guenola Ricard & Toni Gabaldón & Angela H. A. M. van Hoek & Seung Yeo Moon-van der Staay & Werner J. H. Koopman & Jaap, 2005. "An anaerobic mitochondrion that produces hydrogen," Nature, Nature, vol. 434(7029), pages 74-79, March.
  • Handle: RePEc:nat:nature:v:434:y:2005:i:7029:d:10.1038_nature03343
    DOI: 10.1038/nature03343
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