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The genome of the protist parasite Entamoeba histolytica

Author

Listed:
  • Brendan Loftus

    (TIGR)

  • Iain Anderson

    (TIGR)

  • Rob Davies

    (The Sanger Institute, The Wellcome Trust Genome Campus)

  • U. Cecilia M. Alsmark

    (School of Biology, University of Newcastle)

  • John Samuelson

    (Boston University Goldman School of Dental Medicine)

  • Paolo Amedeo

    (TIGR)

  • Paola Roncaglia

    (TIGR)

  • Matt Berriman

    (The Sanger Institute, The Wellcome Trust Genome Campus)

  • Robert P. Hirt

    (School of Biology, University of Newcastle)

  • Barbara J. Mann

    (University of Virginia)

  • Tomo Nozaki

    (National Institute of Infectious Diseases)

  • Bernard Suh

    (TIGR)

  • Mihai Pop

    (TIGR)

  • Michael Duchene

    (Center for Physiology and Pathophysiology, Medical University of Vienna)

  • John Ackers

    (London School of Hygiene and Tropical Medicine)

  • Egbert Tannich

    (Bernhard Nocht Institute for Tropical Medicine)

  • Matthias Leippe

    (University of Kiel)

  • Margit Hofer

    (Center for Physiology and Pathophysiology, Medical University of Vienna)

  • Iris Bruchhaus

    (Bernhard Nocht Institute for Tropical Medicine)

  • Ute Willhoeft

    (Bernhard Nocht Institute for Tropical Medicine)

  • Alok Bhattacharya

    (Jawaharlal Nehru University)

  • Tracey Chillingworth

    (The Sanger Institute, The Wellcome Trust Genome Campus)

  • Carol Churcher

    (The Sanger Institute, The Wellcome Trust Genome Campus)

  • Zahra Hance

    (The Sanger Institute, The Wellcome Trust Genome Campus)

  • Barbara Harris

    (The Sanger Institute, The Wellcome Trust Genome Campus)

  • David Harris

    (The Sanger Institute, The Wellcome Trust Genome Campus)

  • Kay Jagels

    (The Sanger Institute, The Wellcome Trust Genome Campus)

  • Sharon Moule

    (The Sanger Institute, The Wellcome Trust Genome Campus)

  • Karen Mungall

    (The Sanger Institute, The Wellcome Trust Genome Campus)

  • Doug Ormond

    (The Sanger Institute, The Wellcome Trust Genome Campus)

  • Rob Squares

    (The Sanger Institute, The Wellcome Trust Genome Campus)

  • Sally Whitehead

    (The Sanger Institute, The Wellcome Trust Genome Campus)

  • Michael A. Quail

    (The Sanger Institute, The Wellcome Trust Genome Campus)

  • Ester Rabbinowitsch

    (The Sanger Institute, The Wellcome Trust Genome Campus)

  • Halina Norbertczak

    (The Sanger Institute, The Wellcome Trust Genome Campus)

  • Claire Price

    (The Sanger Institute, The Wellcome Trust Genome Campus)

  • Zheng Wang

    (TIGR)

  • Nancy Guillén

    (Institut Pasteur)

  • Carol Gilchrist

    (University of Virginia)

  • Suzanne E. Stroup

    (University of Virginia)

  • Sudha Bhattacharya

    (Jawaharlal Nehru University)

  • Anuradha Lohia

    (Bose Institute)

  • Peter G. Foster

    (The Natural History Museum)

  • Thomas Sicheritz-Ponten

    (Technical University of Denmark)

  • Christian Weber

    (Institut Pasteur)

  • Upinder Singh

    (Stanford University School of Medicine)

  • Chandrama Mukherjee

    (Bose Institute)

  • Najib M. El-Sayed

    (TIGR)

  • William A. Petri

    (University of Virginia)

  • C. Graham Clark

    (London School of Hygiene and Tropical Medicine)

  • T. Martin Embley

    (School of Biology, University of Newcastle)

  • Bart Barrell

    (The Sanger Institute, The Wellcome Trust Genome Campus)

  • Claire M. Fraser

    (TIGR)

  • Neil Hall

    (The Sanger Institute, The Wellcome Trust Genome Campus
    TIGR)

Abstract

Amoebiasis: a well-tuned genome The genome sequence of the pathogen Entamoeba histolytica is reported this week. E. histolytica causes amoebiasis, the second most deadly protozoan disease after malaria. The genome contains adaptations shared with other anaerobic pathogens such as Trichomonas and Giardia. And there is evidence that the genome has been shaped by many gene transfers from bacteria, which may suggest possible targets for drugs against these organisms. The identification of a large number of sensing and signalling proteins challenges the idea that E. histolytica is a simple organism: in fact it is finely attuned to its environment.

Suggested Citation

  • Brendan Loftus & Iain Anderson & Rob Davies & U. Cecilia M. Alsmark & John Samuelson & Paolo Amedeo & Paola Roncaglia & Matt Berriman & Robert P. Hirt & Barbara J. Mann & Tomo Nozaki & Bernard Suh & M, 2005. "The genome of the protist parasite Entamoeba histolytica," Nature, Nature, vol. 433(7028), pages 865-868, February.
    • Handle: RePEc:nat:nature:v:433:y:2005:i:7028:d:10.1038_nature03291
    DOI: 10.1038/nature03291
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