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DRP-1-mediated mitochondrial fragmentation during EGL-1-induced cell death in C. elegans

Author

Listed:
  • Ravi Jagasia

    (Max Planck Institute of Neurobiology
    Universität München
    Dartmouth Medical School)

  • Phillip Grote

    (Dartmouth Medical School)

  • Benedikt Westermann

    (Universität München
    Universität Bayreuth)

  • Barbara Conradt

    (Dartmouth Medical School)

Abstract

Mitochondria: agents of cell death Studies in the nematode Caenorhabditis elegans have been instrumental in the elucidation of the mechanism of apoptosis, the ubiquitous process of programmed cell death required for the elimination of potentially harmful cells. In higher organisms, mitochondria play a crucial role in apoptosis. Now comes evidence that the physical fragmentation of mitochondria is integral to apoptosis in C. elegans too, suggesting that the cell-death activation machinery is universally linked to mitochondria.

Suggested Citation

  • Ravi Jagasia & Phillip Grote & Benedikt Westermann & Barbara Conradt, 2005. "DRP-1-mediated mitochondrial fragmentation during EGL-1-induced cell death in C. elegans," Nature, Nature, vol. 433(7027), pages 754-760, February.
    • Handle: RePEc:nat:nature:v:433:y:2005:i:7027:d:10.1038_nature03316
    DOI: 10.1038/nature03316
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