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Genetically modified Plasmodium parasites as a protective experimental malaria vaccine

Author

Listed:
  • Ann-Kristin Mueller

    (Heidelberg University School of Medicine)

  • Mehdi Labaied

    (Seattle Biomedical Research Institute)

  • Stefan H. I. Kappe

    (Seattle Biomedical Research Institute
    University of Washington)

  • Kai Matuschewski

    (Heidelberg University School of Medicine)

Abstract

Malaria vaccine hope The prospect of large-scale production of an effective malaria vaccine comes a step closer with publication of a study showing that a vaccine made from a live malaria parasite can protect against infection in a rodent malaria model. When an infected female Anopheles mosquito bites a person, Plasmodium parasite can enter the blood. The Plasmodium used in the successful live vaccine is genetically modified by removing the uis3, gene needed for progression to the next stage of its life cycle, in the liver. Mice injected with these weakened parasites developed immunity against normal infectious Plasmodium. A human vaccine using this gene-deletion approach would need to meet high safety standards, so it is still some way off, but proof that it can work is an important advance.

Suggested Citation

  • Ann-Kristin Mueller & Mehdi Labaied & Stefan H. I. Kappe & Kai Matuschewski, 2005. "Genetically modified Plasmodium parasites as a protective experimental malaria vaccine," Nature, Nature, vol. 433(7022), pages 164-167, January.
    • Handle: RePEc:nat:nature:v:433:y:2005:i:7022:d:10.1038_nature03188
    DOI: 10.1038/nature03188
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