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Exploring biology with small organic molecules

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  • Brent R. Stockwell

    (Columbia University)

Abstract

Small organic molecules have proven to be invaluable tools for investigating biological systems, but there is still much to learn from their use. To discover and to use more effectively new chemical tools to understand biology, strategies are needed that allow us to systematically explore ‘biological-activity space’. Such strategies involve analysing both protein binding of, and phenotypic responses to, small organic molecules. The mapping of biological-activity space using small molecules is akin to mapping the stars — uncharted territory is explored using a system of coordinates that describes where each new feature lies.

Suggested Citation

  • Brent R. Stockwell, 2004. "Exploring biology with small organic molecules," Nature, Nature, vol. 432(7019), pages 846-854, December.
    • Handle: RePEc:nat:nature:v:432:y:2004:i:7019:d:10.1038_nature03196
    DOI: 10.1038/nature03196
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    Cited by:

    1. Christelle Reynès & Hélène Host & Anne-Claude Camproux & Guillaume Laconde & Florence Leroux & Anne Mazars & Benoit Deprez & Robin Fahraeus & Bruno O Villoutreix & Olivier Sperandio, 2010. "Designing Focused Chemical Libraries Enriched in Protein-Protein Interaction Inhibitors using Machine-Learning Methods," PLOS Computational Biology, Public Library of Science, vol. 6(3), pages 1-15, March.
    2. Rafał Kurczab & Vittorio Canale & Paweł Zajdel & Andrzej J Bojarski, 2016. "An Algorithm to Identify Target-Selective Ligands – A Case Study of 5-HT7/5-HT1A Receptor Selectivity," PLOS ONE, Public Library of Science, vol. 11(6), pages 1-18, June.

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