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Lessons from natural molecules

Author

Listed:
  • Jon Clardy

    (Harvard Medical School)

  • Christopher Walsh

    (Harvard Medical School)

Abstract

Natural products have inspired chemists and physicians for millennia. Their rich structural diversity and complexity has prompted synthetic chemists to produce them in the laboratory, often with therapeutic applications in mind, and many drugs used today are natural products or natural-product derivatives. Recent years have seen considerable advances in our understanding of natural-product biosynthesis. Coupled with improvements in approaches for natural-product isolation, characterization and synthesis, these could be opening the door to a new era in the investigation of natural products in academia and industry.

Suggested Citation

  • Jon Clardy & Christopher Walsh, 2004. "Lessons from natural molecules," Nature, Nature, vol. 432(7019), pages 829-837, December.
  • Handle: RePEc:nat:nature:v:432:y:2004:i:7019:d:10.1038_nature03194
    DOI: 10.1038/nature03194
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    Cited by:

    1. Jiangyong Gu & Yuanshen Gui & Lirong Chen & Gu Yuan & Hui-Zhe Lu & Xiaojie Xu, 2013. "Use of Natural Products as Chemical Library for Drug Discovery and Network Pharmacology," PLOS ONE, Public Library of Science, vol. 8(4), pages 1-10, April.
    2. Jiadong Hu & Shi Qiu & Feiyan Wang & Qing Li & Chun-Lei Xiang & Peng Di & Ziding Wu & Rui Jiang & Jinxing Li & Zhen Zeng & Jing Wang & Xingxing Wang & Yuchen Zhang & Shiyuan Fang & Yuqi Qiao & Jie Din, 2023. "Functional divergence of CYP76AKs shapes the chemodiversity of abietane-type diterpenoids in genus Salvia," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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