Author
Listed:
- John W. Wallis
(Washington University School of Medicine, Campus Box 8501)
- Jan Aerts
(Wageningen University)
- Martien A. M. Groenen
(Wageningen University)
- Richard P. M. A. Crooijmans
(Wageningen University)
- Dan Layman
(Washington University School of Medicine, Campus Box 8501)
- Tina A. Graves
(Washington University School of Medicine, Campus Box 8501)
- Debra E. Scheer
(Washington University School of Medicine, Campus Box 8501)
- Colin Kremitzki
(Washington University School of Medicine, Campus Box 8501)
- Mary J. Fedele
(Washington University School of Medicine, Campus Box 8501)
- Nancy K. Mudd
(Washington University School of Medicine, Campus Box 8501)
- Marco Cardenas
(Washington University School of Medicine, Campus Box 8501)
- Jamey Higginbotham
(Washington University School of Medicine, Campus Box 8501)
- Jason Carter
(Washington University School of Medicine, Campus Box 8501)
- Rebecca McGrane
(Washington University School of Medicine, Campus Box 8501)
- Tony Gaige
(Washington University School of Medicine, Campus Box 8501)
- Kelly Mead
(Washington University School of Medicine, Campus Box 8501)
- Jason Walker
(Washington University School of Medicine, Campus Box 8501)
- Derek Albracht
(Washington University School of Medicine, Campus Box 8501)
- Jonathan Davito
(Washington University School of Medicine, Campus Box 8501)
- Shiaw-Pyng Yang
(Washington University School of Medicine, Campus Box 8501)
- Shin Leong
(Washington University School of Medicine, Campus Box 8501)
- Asif Chinwalla
(Washington University School of Medicine, Campus Box 8501)
- Mandeep Sekhon
(Washington University School of Medicine, Campus Box 8501)
- Kristine Wylie
(Washington University School of Medicine, Campus Box 8501)
- Jerry Dodgson
(Michigan State University)
- Michael N. Romanov
(Michigan State University)
- Hans Cheng
(Agricultural Research Service, USDA)
- Pieter J. de Jong
(Children's Hospital Oakland Research Institute)
- Kazutoyo Osoegawa
(Children's Hospital Oakland Research Institute)
- Mikhail Nefedov
(Children's Hospital Oakland Research Institute)
- Hongbin Zhang
(Texas A&M University)
- John D. McPherson
(Baylor College of Medicine, One Baylor Plaza Houston)
- Martin Krzywinski
(Genome Sciences Centre, British Columbia Cancer Agency)
- Jacquie Schein
(Genome Sciences Centre, British Columbia Cancer Agency)
- LaDeana Hillier
(Washington University School of Medicine, Campus Box 8501)
- Elaine R. Mardis
(Washington University School of Medicine, Campus Box 8501)
- Richard K. Wilson
(Washington University School of Medicine, Campus Box 8501)
- Wesley C. Warren
(Washington University School of Medicine, Campus Box 8501)
Abstract
Strategies for assembling large, complex genomes have evolved to include a combination of whole-genome shotgun sequencing and hierarchal map-assisted sequencing1,2. Whole-genome maps of all types can aid genome assemblies, generally starting with low-resolution cytogenetic maps and ending with the highest resolution of sequence. Fingerprint clone maps are based upon complete restriction enzyme digests of clones representative of the target genome, and ultimately comprise a near-contiguous path of clones across the genome. Such clone-based maps are used to validate sequence assembly order, supply long-range linking information for assembled sequences, anchor sequences to the genetic map and provide templates for closing gaps. Fingerprint maps are also a critical resource for subsequent functional genomic studies, because they provide a redundant and ordered sampling of the genome with clones3. In an accompanying paper4 we describe the draft genome sequence of the chicken, Gallus gallus, the first species sequenced that is both a model organism and a global food source. Here we present a clone-based physical map of the chicken genome at 20-fold coverage, containing 260 contigs of overlapping clones. This map represents approximately 91% of the chicken genome and enables identification of chicken clones aligned to positions in other sequenced genomes.
Suggested Citation
John W. Wallis & Jan Aerts & Martien A. M. Groenen & Richard P. M. A. Crooijmans & Dan Layman & Tina A. Graves & Debra E. Scheer & Colin Kremitzki & Mary J. Fedele & Nancy K. Mudd & Marco Cardenas & J, 2004.
"A physical map of the chicken genome,"
Nature, Nature, vol. 432(7018), pages 761-764, December.
Handle:
RePEc:nat:nature:v:432:y:2004:i:7018:d:10.1038_nature03030
DOI: 10.1038/nature03030
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