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Aneuploidy and cancer

Author

Listed:
  • Harith Rajagopalan

    (The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine)

  • Christoph Lengauer

    (The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine)

Abstract

In contrast to normal cells, aneuploidy — alterations in the number of chromosomes — is consistently observed in virtually all cancers. A growing body of evidence suggests that aneuploidy is often caused by a particular type of genetic instability, called chromosomal instability, which may reflect defects in mitotic segregation in cancer cells. A better understanding of the molecular mechanisms leading to aneuploidy holds promise for the development of cancer drugs that target this process.

Suggested Citation

  • Harith Rajagopalan & Christoph Lengauer, 2004. "Aneuploidy and cancer," Nature, Nature, vol. 432(7015), pages 338-341, November.
    • Handle: RePEc:nat:nature:v:432:y:2004:i:7015:d:10.1038_nature03099
    DOI: 10.1038/nature03099
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    Cited by:

    1. Zaili Luo & Dazhuan Xin & Yunfei Liao & Kalen Berry & Sean Ogurek & Feng Zhang & Liguo Zhang & Chuntao Zhao & Rohit Rao & Xinran Dong & Hao Li & Jianzhong Yu & Yifeng Lin & Guoying Huang & Lingli Xu &, 2023. "Loss of phosphatase CTDNEP1 potentiates aggressive medulloblastoma by triggering MYC amplification and genomic instability," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    2. Yingxiang Li & Xujun Wang & Haiyang Zheng & Chengyang Wang & Stéphane Minvielle & Florence Magrangeas & Hervé Avet-Loiseau & Parantu K Shah & Yong Zhang & Nikhil C Munshi & Cheng Li, 2013. "Classify Hyperdiploidy Status of Multiple Myeloma Patients Using Gene Expression Profiles," PLOS ONE, Public Library of Science, vol. 8(3), pages 1-11, March.
    3. Yaping Huang & Changzheng Lu & Hanzhi Wang & Liya Gu & Yang-Xin Fu & Guo-Min Li, 2023. "DNAJA2 deficiency activates cGAS-STING pathway via the induction of aberrant mitosis and chromosome instability," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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