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Neutral evolution of ‘non-coding’ complementary DNAs

Author

Listed:
  • Jun Wang

    (James D. Watson Institute of Genome Sciences of Zhejiang University, Hangzhou Genomics Institute
    Beijing Institute of Genomics of the Chinese Academy of Sciences)

  • Jianguo Zhang

    (Beijing Institute of Genomics of the Chinese Academy of Sciences)

  • Hongkun Zheng

    (Beijing Institute of Genomics of the Chinese Academy of Sciences)

  • Jun Li

    (Beijing Institute of Genomics of the Chinese Academy of Sciences)

  • Dongyuan Liu

    (Beijing Institute of Genomics of the Chinese Academy of Sciences)

  • Heng Li

    (Beijing Institute of Genomics of the Chinese Academy of Sciences)

  • Ram Samudrala

    (Computation Genomics Group, University of Washington)

  • Jun Yu

    (James D. Watson Institute of Genome Sciences of Zhejiang University, Hangzhou Genomics Institute
    Beijing Institute of Genomics of the Chinese Academy of Sciences)

  • Gane Ka-Shu Wong

    (James D. Watson Institute of Genome Sciences of Zhejiang University, Hangzhou Genomics Institute
    Beijing Institute of Genomics of the Chinese Academy of Sciences
    University of Washington Genome Center)

Abstract

(Arising from: Y. Okazaki et al. Nature 420, 563–573 200210.1038/nature01266 ; Okazaki et al. reply) Okazaki et al. have argued that as many as 15,815 of 33,409 non-redundant mouse complementary DNAs may represent functional RNA genes1, on the basis of their findings that some of these cDNAs are confirmed by expressed sequence tagging and are found near CpG islands or polyadenylation signals2 — although many are expressed at such low levels that they could not be detected by microarray analysis3. We show here that conservation of these ‘non-coding’ cDNAs in rats or humans is no better than in an evolutionarily neutral control. Our results indicate that they are either non-functional or, if they are functional, are specific to a given species.

Suggested Citation

  • Jun Wang & Jianguo Zhang & Hongkun Zheng & Jun Li & Dongyuan Liu & Heng Li & Ram Samudrala & Jun Yu & Gane Ka-Shu Wong, 2004. "Neutral evolution of ‘non-coding’ complementary DNAs," Nature, Nature, vol. 431(7010), pages 1-2, October.
    • Handle: RePEc:nat:nature:v:431:y:2004:i:7010:d:10.1038_nature03016
    DOI: 10.1038/nature03016
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