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Intragenic ERBB2 kinase mutations in tumours

Author

Listed:
  • Philip Stephens

    (Cancer Genome Project, Wellcome Trust Sanger Institute
    Cancer Genome Project and Collaborative Group)

  • Chris Hunter

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Graham Bignell

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Sarah Edkins

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Helen Davies

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Jon Teague

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Claire Stevens

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Sarah O'Meara

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Raffaella Smith

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Adrian Parker

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Andy Barthorpe

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Matthew Blow

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Lisa Brackenbury

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Adam Butler

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Oliver Clarke

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Jennifer Cole

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Ed Dicks

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Angus Dike

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Anja Drozd

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Ken Edwards

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Simon Forbes

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Rebecca Foster

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Kristian Gray

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Chris Greenman

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Kelly Halliday

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Katy Hills

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Vivienne Kosmidou

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Richard Lugg

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Andy Menzies

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Janet Perry

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Robert Petty

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Keiran Raine

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Lewis Ratford

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Rebecca Shepherd

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Alexandra Small

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Yvonne Stephens

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Calli Tofts

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Jennifer Varian

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Sofie West

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Sara Widaa

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Andrew Yates

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Francis Brasseur

    (Ludwig Institute for Cancer Research)

  • Colin S. Cooper

    (Institute of Cancer Research)

  • Adrienne M. Flanagan

    (Institute of Orthopaedics, University College London)

  • Margaret Knowles

    (Cancer Research UK Clinical Centre, St James's University Hospital)

  • Suet Y. Leung

    (Queen Mary Hospital)

  • David N. Louis

    (Massachusetts General Hospital East, Molecular Pathology Unit)

  • Leendert H. J. Looijenga

    (Laboratory of Pathology/Experimental Patho-Oncology, Erasmus MC University Medical Center Rotterdam, Daniel den Hoed Cancer Center, Josephine Nefkens Institute)

  • Bruce Malkowicz

    (University of Pennsylvania Division of Urology)

  • Marco A. Pierotti

    (Instituto Nazionale Tumori and FIRC Institute of Molecular Oncology)

  • Bin Teh

    (Laboratory of Cancer Genetics, Van Andel Research Institute)

  • Georgia Chenevix-Trench

    (Queensland Institute of Medical Research, Royal Brisbane Hospital)

  • Barbara L. Weber

    (University of Pennsylvania Cancer Centre)

  • Siu T. Yuen

    (Queen Mary Hospital)

  • Grace Harris

    (Royal Brompton Hospital)

  • Peter Goldstraw

    (Royal Brompton Hospital)

  • Andrew G. Nicholson

    (Royal Brompton Hospital)

  • P. Andrew Futreal

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Richard Wooster

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Michael R. Stratton

    (Cancer Genome Project, Wellcome Trust Sanger Institute
    Institute of Cancer Research)

Abstract

The protein-kinase family is the most frequently mutated gene family found in human cancer and faulty kinase enzymes are being investigated as promising targets for the design of antitumour therapies. We have sequenced the gene encoding the transmembrane protein tyrosine kinase ERBB2 (also known as HER2 or Neu) from 120 primary lung tumours and identified 4% that have mutations within the kinase domain; in the adenocarcinoma subtype of lung cancer, 10% of cases had mutations. ERBB2 inhibitors, which have so far proved to be ineffective in treating lung cancer, should now be clinically re-evaluated in the specific subset of patients with lung cancer whose tumours carry ERBB2 mutations.

Suggested Citation

  • Philip Stephens & Chris Hunter & Graham Bignell & Sarah Edkins & Helen Davies & Jon Teague & Claire Stevens & Sarah O'Meara & Raffaella Smith & Adrian Parker & Andy Barthorpe & Matthew Blow & Lisa Bra, 2004. "Intragenic ERBB2 kinase mutations in tumours," Nature, Nature, vol. 431(7008), pages 525-526, September.
    • Handle: RePEc:nat:nature:v:431:y:2004:i:7008:d:10.1038_431525b
    DOI: 10.1038/431525b
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