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Spermatid differentiation requires the assembly of a cell polarity complex downstream of junctional adhesion molecule-C

Author

Listed:
  • Georgia Gliki

    (Cancer Research UK London Research Institute)

  • Klaus Ebnet

    (University Hospital Muenster)

  • Michel Aurrand-Lions

    (University of Geneva, CMU)

  • Beat A. Imhof

    (University of Geneva, CMU)

  • Ralf H. Adams

    (Cancer Research UK London Research Institute)

Abstract

During spermatogenesis in the mammalian testis, stem cells (spermatogonia) differentiate into spermatocytes, which subsequently undergo two consecutive meiotic divisions to give rise to haploid spermatids. These cells are initially round but progressively elongate, condense their nuclei, acquire flagellar and acrosomal structures, and shed a significant amount of their cytoplasm to form spermatozoa (the sperm cells) in a developmental cascade termed spermiogenesis1,2. Defects in these processes will lead to a lack of mature sperm cells (azoospermia), which is a major cause of male infertility in the human population3. Here we report that a cell-surface protein of the immunoglobulin superfamily, junctional adhesion molecule-C (JAM-C), is critically required for the differentiation of round spermatids into spermatozoa in mice. We found that Jam-C is essential for the polarization of round spermatids, a function that we attribute to its role in the assembly of a cell polarity complex.

Suggested Citation

  • Georgia Gliki & Klaus Ebnet & Michel Aurrand-Lions & Beat A. Imhof & Ralf H. Adams, 2004. "Spermatid differentiation requires the assembly of a cell polarity complex downstream of junctional adhesion molecule-C," Nature, Nature, vol. 431(7006), pages 320-324, September.
    • Handle: RePEc:nat:nature:v:431:y:2004:i:7006:d:10.1038_nature02877
    DOI: 10.1038/nature02877
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