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Translating cell biology in vitro to immunity in vivo

Author

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  • Marianne Boes

    (Harvard Medical School
    Harvard Institutes of Medicine)

  • Hidde L. Ploegh

    (Harvard Medical School)

Abstract

The elimination of pathogens and pathogen-infected cells initially rests on the rapid deployment of innate immune defences. Should these defences fail, it is the lymphocytes — T cells and B cells — with their antigen-specific receptors that must rise to the task of providing adaptive immunity. Technological advances are now allowing immunologists to correlate data obtained in vitro with in vivo functions. A better understanding of T-cell activation in vivo could lead to more effective strategies for the treatment and prevention of infectious and autoimmmune diseases.

Suggested Citation

  • Marianne Boes & Hidde L. Ploegh, 2004. "Translating cell biology in vitro to immunity in vivo," Nature, Nature, vol. 430(6996), pages 264-271, July.
    • Handle: RePEc:nat:nature:v:430:y:2004:i:6996:d:10.1038_nature02762
    DOI: 10.1038/nature02762
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