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Does gut hormone PYY3–36 decrease food intake in rodents?

Author

Listed:
  • M. Tschöp

    (University of Cincinnati Genome Research Institute
    German Institute of Human Nutrition)

  • T. R. Castañeda

    (University of Cincinnati Genome Research Institute
    German Institute of Human Nutrition)

  • H. G. Joost

    (German Institute of Human Nutrition)

  • C. Thöne-Reineke

    (Center for Cardiovascular Research, Institute for Pharmacology and Toxicology, Charité University Hospital)

  • S. Ortmann

    (German Institute of Human Nutrition
    Institute for Zoo and Wildlife Research)

  • S. Klaus

    (German Institute of Human Nutrition)

  • M. M. Hagan

    (University of Alabama at Birmingham)

  • P. C. Chandler

    (University of Alabama at Birmingham)

  • K. D. Oswald

    (University of Alabama at Birmingham)

  • S. C. Benoit

    (University of Cincinnati Genome Research Institute)

  • R. J. Seeley

    (University of Cincinnati Genome Research Institute)

  • K. P. Kinzig

    (Johns Hopkins University School of Medicine)

  • T. H. Moran

    (Johns Hopkins University School of Medicine)

  • A. G. Beck-Sickinger

    (Institute of Biochemistry, University of Leipzig)

  • N. Koglin

    (Institute of Biochemistry, University of Leipzig)

  • R. J. Rodgers

    (Behavioural Pharmacology Laboratory, School of Psychology, University of Leeds)

  • J. E. Blundell

    (Behavioural Pharmacology Laboratory, School of Psychology, University of Leeds)

  • Y. Ishii

    (Behavioural Pharmacology Laboratory, School of Psychology, University of Leeds)

  • A. H. Beattie

    (Behavioural Pharmacology Laboratory, School of Psychology, University of Leeds)

  • P. Holch

    (Behavioural Pharmacology Laboratory, School of Psychology, University of Leeds)

  • D. B. Allison

    (Section on Statistical Genetics, University of Alabama at Birmingham)

  • K. Raun

    (Novo Nordisk A/S, Discovery)

  • K. Madsen

    (Novo Nordisk A/S, Discovery)

  • B. S. Wulff

    (Novo Nordisk A/S, Discovery)

  • C. E. Stidsen

    (Novo Nordisk A/S, Discovery)

  • M. Birringer

    (Peptides and Elephants GmbH)

  • O. J. Kreuzer

    (Peptides and Elephants GmbH)

  • M. Schindler

    (Boehringer-Ingelheim Pharma GmbH and Co. KG)

  • K. Arndt

    (Boehringer-Ingelheim Pharma GmbH and Co. KG)

  • K. Rudolf

    (Boehringer-Ingelheim Pharma GmbH and Co. KG)

  • M. Mark

    (Boehringer-Ingelheim Pharma GmbH and Co. KG)

  • X. Y. Deng

    (Hepatology and Nutrition, University of Pittsburgh)

  • D. C. Withcomb

    (Hepatology and Nutrition, University of Pittsburgh)

  • H. Halem

    (Biomeasure Incorporated/Ipsen Group)

  • J. Taylor

    (Biomeasure Incorporated/Ipsen Group)

  • J. Dong

    (Biomeasure Incorporated/Ipsen Group)

  • R. Datta

    (Biomeasure Incorporated/Ipsen Group)

  • M. Culler

    (Biomeasure Incorporated/Ipsen Group)

  • S. Craney

    (Eli Lilly & Co. Research Laboratories)

  • D. Flora

    (Eli Lilly & Co. Research Laboratories)

  • D. Smiley

    (Eli Lilly & Co. Research Laboratories)

  • M. L. Heiman

    (Eli Lilly & Co. Research Laboratories)

Abstract

Arising from: R. L. Batterham et al. Nature 418, 650–654 (2002); Batterham et al. reply Batterham et al. report that the gut peptide hormone PYY3–36 decreases food intake and body-weight gain in rodents1, a discovery that has been heralded as potentially offering a new therapy for obesity. However, we have been unable to replicate their results. Although the reasons for this discrepancy remain undetermined, an effective anti-obesity drug ultimately must produce its effects across a range of situations. The fact that the findings of Batterham et al.1 cannot easily be replicated calls into question the potential value of an anti-obesity approach that is based on administration of PYY3–36.

Suggested Citation

  • M. Tschöp & T. R. Castañeda & H. G. Joost & C. Thöne-Reineke & S. Ortmann & S. Klaus & M. M. Hagan & P. C. Chandler & K. D. Oswald & S. C. Benoit & R. J. Seeley & K. P. Kinzig & T. H. Moran & A. G. Be, 2004. "Does gut hormone PYY3–36 decrease food intake in rodents?," Nature, Nature, vol. 430(6996), pages 1-3, July.
    • Handle: RePEc:nat:nature:v:430:y:2004:i:6996:d:10.1038_nature02665
    DOI: 10.1038/nature02665
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