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A marker for Stevens–Johnson syndrome

Author

Listed:
  • Wen-Hung Chung

    (Chang Gung Memorial Hospital)

  • Shuen-Iu Hung

    (Institute of Biomedical Sciences, Academia Sinica)

  • Hong-Shang Hong

    (Chang Gung Memorial Hospital)

  • Mo-Song Hsih

    (Chang Gung Memorial Hospital)

  • Li-Cheng Yang

    (Chang Gung Memorial Hospital)

  • Hsin-Chun Ho

    (Chang Gung Memorial Hospital)

  • Jer-Yuarn Wu

    (Institute of Biomedical Sciences, Academia Sinica
    China Medical University Hospital)

  • Yuan-Tsong Chen

    (Institute of Biomedical Sciences, Academia Sinica
    Duke University Medical Center)

Abstract

Stevens–Johnson syndrome and the related disease toxic epidermal necrolysis are life-threatening reactions of the skin to particular types of medication1,2,3. Here we show that there is a strong association in Han Chinese between a genetic marker, the human leukocyte antigen HLA–B*1502, and Stevens–Johnson syndrome induced by carbamazepine, a drug commonly prescribed for the treatment of seizures. It should be possible to exploit this association in a highly reliable test to predict severe adverse reaction, as well as for investigation of the pathogenesis of Stevens–Johnson syndrome.

Suggested Citation

  • Wen-Hung Chung & Shuen-Iu Hung & Hong-Shang Hong & Mo-Song Hsih & Li-Cheng Yang & Hsin-Chun Ho & Jer-Yuarn Wu & Yuan-Tsong Chen, 2004. "A marker for Stevens–Johnson syndrome," Nature, Nature, vol. 428(6982), pages 486-486, April.
    • Handle: RePEc:nat:nature:v:428:y:2004:i:6982:d:10.1038_428486a
    DOI: 10.1038/428486a
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