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Creation of long-lasting blood vessels

Author

Listed:
  • Naoto Koike

    (Edwin L. Steele Laboratory, Massachusetts General Hospital, Harvard Medical School)

  • Dai Fukumura

    (Edwin L. Steele Laboratory, Massachusetts General Hospital, Harvard Medical School)

  • Oliver Gralla

    (Edwin L. Steele Laboratory, Massachusetts General Hospital, Harvard Medical School)

  • Patrick Au

    (Edwin L. Steele Laboratory, Massachusetts General Hospital, Harvard Medical School)

  • Jeffrey S. Schechner

    (Edwin L. Steele Laboratory, Massachusetts General Hospital, Harvard Medical School)

  • Rakesh K. Jain

    (Edwin L. Steele Laboratory, Massachusetts General Hospital, Harvard Medical School
    Yale University School of Medicine)

Abstract

The construction of stable blood vessels is a fundamental challenge for tissue engineering in regenerative medicine. Although certain genes can be introduced into vascular cells to enhance their survival and proliferation, these manipulations may be oncogenic. We show here that a network of long-lasting blood vessels can be formed in mice by co-implantation of vascular endothelial cells and mesenchymal precursor cells, by-passing the need for risky genetic manipulations. These networks are stable and functional for one year in vivo.

Suggested Citation

  • Naoto Koike & Dai Fukumura & Oliver Gralla & Patrick Au & Jeffrey S. Schechner & Rakesh K. Jain, 2004. "Creation of long-lasting blood vessels," Nature, Nature, vol. 428(6979), pages 138-139, March.
    • Handle: RePEc:nat:nature:v:428:y:2004:i:6979:d:10.1038_428138a
    DOI: 10.1038/428138a
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