IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v428y2004i6978d10.1038_nature02375.html
   My bibliography  Save this article

Mice cloned from olfactory sensory neurons

Author

Listed:
  • Kevin Eggan

    (Massachusetts Institute of Technology
    Harvard University)

  • Kristin Baldwin

    (Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University)

  • Michael Tackett

    (Massachusetts Institute of Technology)

  • Joseph Osborne

    (Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University
    College of Physicians and Surgeons, Columbia University)

  • Joseph Gogos

    (Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University)

  • Andrew Chess

    (Massachusetts Institute of Technology)

  • Richard Axel

    (Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University)

  • Rudolf Jaenisch

    (Massachusetts Institute of Technology)

Abstract

Cloning by nuclear transplantation has been successfully carried out in various mammals, including mice. Until now mice have not been cloned from post-mitotic cells such as neurons. Here, we have generated fertile mouse clones derived by transferring the nuclei of post-mitotic, olfactory sensory neurons into oocytes. These results indicate that the genome of a post-mitotic, terminally differentiated neuron can re-enter the cell cycle and be reprogrammed to a state of totipotency after nuclear transfer. Moreover, the pattern of odorant receptor gene expression and the organization of odorant receptor genes in cloned mice was indistinguishable from wild-type animals, indicating that irreversible changes to the DNA of olfactory neurons do not accompany receptor gene choice.

Suggested Citation

  • Kevin Eggan & Kristin Baldwin & Michael Tackett & Joseph Osborne & Joseph Gogos & Andrew Chess & Richard Axel & Rudolf Jaenisch, 2004. "Mice cloned from olfactory sensory neurons," Nature, Nature, vol. 428(6978), pages 44-49, March.
    • Handle: RePEc:nat:nature:v:428:y:2004:i:6978:d:10.1038_nature02375
    DOI: 10.1038/nature02375
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature02375
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature02375?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:428:y:2004:i:6978:d:10.1038_nature02375. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.