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Cks1-dependent proteasome recruitment and activation of CDC20 transcription in budding yeast

Author

Listed:
  • May C. Morris

    (The Scripps Research Institute, Department of Molecular Biology
    Centre de Recherches en Biochimie Macromoléculaire—CNRS-UPR1086)

  • Peter Kaiser

    (The Scripps Research Institute, Department of Molecular Biology
    University of California Irvine, Department of Biological Chemistry)

  • Stanislav Rudyak

    (The Scripps Research Institute, Department of Molecular Biology)

  • Chris Baskerville

    (The Scripps Research Institute, Department of Molecular Biology)

  • Mark H. Watson

    (The Scripps Research Institute, Department of Molecular Biology
    Gemin X Biotechnologies Inc.)

  • Steven I. Reed

    (The Scripps Research Institute, Department of Molecular Biology)

Abstract

Cks proteins are small evolutionarily conserved proteins that interact genetically and physically with cyclin-dependent kinases. However, in spite of a large body of genetic, biochemical and structural research, no compelling unifying model of their functions has emerged1,2. Here we show, by investigating the essential role of Cks1 in Saccharomyces cerevisiae, that the protein is primarily involved in promoting mitosis by modulating the transcriptional activation of the APC/C protein–ubiquitin ligase activator Cdc20. Cks1 is required for both the periodic dissociation of Cdc28 kinase from the CDC20 promoter and the periodic association of the proteasome with the promoter. We propose that the essential role of Cks1 is to recruit the proteasome to, and/or dissociate the Cdc28 kinase from, the CDC20 promoter, thus facilitating transcription by remodelling transcriptional complexes or chromatin associated with the CDC20 gene.

Suggested Citation

  • May C. Morris & Peter Kaiser & Stanislav Rudyak & Chris Baskerville & Mark H. Watson & Steven I. Reed, 2003. "Cks1-dependent proteasome recruitment and activation of CDC20 transcription in budding yeast," Nature, Nature, vol. 423(6943), pages 1009-1013, June.
    • Handle: RePEc:nat:nature:v:423:y:2003:i:6943:d:10.1038_nature01720
    DOI: 10.1038/nature01720
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