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Control of osteoblast function and regulation of bone mass

Author

Listed:
  • Shun-ichi Harada

    (Merck Research Laboratories)

  • Gideon A. Rodan

    (Merck Research Laboratories)

Abstract

The skeleton is an efficient 'servo' (feedback-controlled/steady-state) system that continuously integrates signals and responses which sustain its functions of delivering calcium while maintaining strength. In many individuals, bone mass homeostasis starts failing in midlife, leading to bone loss, osteoporosis and debilitating fractures. Recent advances, spearheaded by genetic information, offer the opportunity to stop or reverse this downhill course.

Suggested Citation

  • Shun-ichi Harada & Gideon A. Rodan, 2003. "Control of osteoblast function and regulation of bone mass," Nature, Nature, vol. 423(6937), pages 349-355, May.
    • Handle: RePEc:nat:nature:v:423:y:2003:i:6937:d:10.1038_nature01660
    DOI: 10.1038/nature01660
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    Cited by:

    1. Faisal E. Aljofi & Aminah Alesawy & Bader Alzaben & Marwa Alshaikh & Norah Alotaibi & Hajer A. Aldulaijan & Sami Alshehri & Eman Aljoghaiman & Yousif A. Al-Dulaijan & Mishali AlSharief, 2023. "Impact of Metformin on Periodontal and Peri-Implant Soft and Hard Tissue," IJERPH, MDPI, vol. 20(2), pages 1-12, January.

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