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A new redox-cofactor vitamin for mammals

Author

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  • Takaoki Kasahara

    (Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN)

  • Tadafumi Kato

    (Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN)

Abstract

Nicotinamides and flavins are essential cofactors in enzyme-catalysed reduction–oxidation (redox) reactions and are classified as vitamins because they must be supplied in the diet. Another redox cofactor, pyrroloquinoline quinone (PQQ), was first discovered in bacteria1 and is also likely to be important in mammals2,3, but the biochemical pathways in which it participates are unknown. Here we identify a PQQ-dependent dehydrogenase enzyme that is crucial for the degradation of the amino acid lysine in mice. PQQ is acting as a mammalian redox cofactor in this reaction, and therefore qualifies as a newcomer to the B group of vitamins.

Suggested Citation

  • Takaoki Kasahara & Tadafumi Kato, 2003. "A new redox-cofactor vitamin for mammals," Nature, Nature, vol. 422(6934), pages 832-832, April.
    • Handle: RePEc:nat:nature:v:422:y:2003:i:6934:d:10.1038_422832a
    DOI: 10.1038/422832a
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