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The DNA sequence and analysis of human chromosome 14

Author

Listed:
  • Roland Heilig

    (Genoscope-Centre National de Séquençage
    UMR-8030, CNRS et Université d'Evry)

  • Ralph Eckenberg

    (Genoscope-Centre National de Séquençage
    UMR-8030, CNRS et Université d'Evry)

  • Jean-Louis Petit

    (Genoscope-Centre National de Séquençage
    UMR-8030, CNRS et Université d'Evry)

  • Núria Fonknechten

    (Genoscope-Centre National de Séquençage
    UMR-8030, CNRS et Université d'Evry)

  • Corinne Da Silva

    (Genoscope-Centre National de Séquençage
    UMR-8030, CNRS et Université d'Evry)

  • Laurence Cattolico

    (Genoscope-Centre National de Séquençage)

  • Michaël Levy

    (Genoscope-Centre National de Séquençage)

  • Valérie Barbe

    (Genoscope-Centre National de Séquençage)

  • Véronique de Berardinis

    (Genoscope-Centre National de Séquençage)

  • Abel Ureta-Vidal

    (Genoscope-Centre National de Séquençage)

  • Eric Pelletier

    (Genoscope-Centre National de Séquençage
    UMR-8030, CNRS et Université d'Evry)

  • Virginie Vico

    (Genoscope-Centre National de Séquençage)

  • Véronique Anthouard

    (Genoscope-Centre National de Séquençage)

  • Lee Rowen

    (Institute for Systems Biology)

  • Anup Madan

    (Institute for Systems Biology)

  • Shizhen Qin

    (Institute for Systems Biology)

  • Hui Sun

    (Genome Sequencing Center, Washington University School of Medicine)

  • Hui Du

    (Genome Sequencing Center, Washington University School of Medicine)

  • Kymberlie Pepin

    (Genome Sequencing Center, Washington University School of Medicine)

  • François Artiguenave

    (Genoscope-Centre National de Séquençage)

  • Catherine Robert

    (Genoscope-Centre National de Séquençage)

  • Corinne Cruaud

    (Genoscope-Centre National de Séquençage)

  • Thomas Brüls

    (Genoscope-Centre National de Séquençage)

  • Olivier Jaillon

    (Genoscope-Centre National de Séquençage
    UMR-8030, CNRS et Université d'Evry)

  • Lucie Friedlander

    (Genoscope-Centre National de Séquençage)

  • Gaelle Samson

    (Genoscope-Centre National de Séquençage
    UMR-8030, CNRS et Université d'Evry)

  • Philippe Brottier

    (Genoscope-Centre National de Séquençage)

  • Susan Cure

    (Genoscope-Centre National de Séquençage)

  • Béatrice Ségurens

    (Genoscope-Centre National de Séquençage)

  • Franck Anière

    (Genoscope-Centre National de Séquençage)

  • Sylvie Samain

    (Genoscope-Centre National de Séquençage)

  • Hervé Crespeau

    (Genoscope-Centre National de Séquençage)

  • Nissa Abbasi

    (Institute for Systems Biology)

  • Nathalie Aiach

    (Genoscope-Centre National de Séquençage)

  • Didier Boscus

    (Genoscope-Centre National de Séquençage)

  • Rachel Dickhoff

    (Institute for Systems Biology)

  • Monica Dors

    (Institute for Systems Biology)

  • Ivan Dubois

    (Genoscope-Centre National de Séquençage)

  • Cynthia Friedman

    (Institute for Systems Biology)

  • Michel Gouyvenoux

    (Genoscope-Centre National de Séquençage)

  • Rose James

    (Institute for Systems Biology)

  • Anuradha Madan

    (Institute for Systems Biology)

  • Barbara Mairey–Estrada

    (Genoscope-Centre National de Séquençage)

  • Sophie Mangenot

    (Genoscope-Centre National de Séquençage)

  • Nathalie Martins

    (Genoscope-Centre National de Séquençage)

  • Manuela Ménard

    (Genoscope-Centre National de Séquençage)

  • Sophie Oztas

    (Genoscope-Centre National de Séquençage)

  • Amber Ratcliffe

    (Institute for Systems Biology)

  • Tristan Shaffer

    (Institute for Systems Biology)

  • Barbara Trask

    (Institute for Systems Biology)

  • Benoit Vacherie

    (Genoscope-Centre National de Séquençage)

  • Chadia Bellemere

    (Genoscope-Centre National de Séquençage)

  • Caroline Belser

    (Genoscope-Centre National de Séquençage)

  • Marielle Besnard-Gonnet

    (Genoscope-Centre National de Séquençage)

  • Delphine Bartol–Mavel

    (Genoscope-Centre National de Séquençage)

  • Magali Boutard

    (Genoscope-Centre National de Séquençage)

  • Stéphanie Briez-Silla

    (Genoscope-Centre National de Séquençage)

  • Stephane Combette

    (Genoscope-Centre National de Séquençage)

  • Virginie Dufossé-Laurent

    (Genoscope-Centre National de Séquençage)

  • Carolyne Ferron

    (Genoscope-Centre National de Séquençage)

  • Christophe Lechaplais

    (Genoscope-Centre National de Séquençage)

  • Claudine Louesse

    (Genoscope-Centre National de Séquençage)

  • Delphine Muselet

    (Genoscope-Centre National de Séquençage)

  • Ghislaine Magdelenat

    (Genoscope-Centre National de Séquençage)

  • Emilie Pateau

    (Genoscope-Centre National de Séquençage)

  • Emmanuelle Petit

    (Genoscope-Centre National de Séquençage)

  • Peggy Sirvain-Trukniewicz

    (Genoscope-Centre National de Séquençage)

  • Arnaud Trybou

    (Genoscope-Centre National de Séquençage)

  • Nathalie Vega-Czarny

    (Genoscope-Centre National de Séquençage)

  • Elodie Bataille

    (Genoscope-Centre National de Séquençage)

  • Elodie Bluet

    (Genoscope-Centre National de Séquençage)

  • Isabelle Bordelais

    (Genoscope-Centre National de Séquençage)

  • Maria Dubois

    (Genoscope-Centre National de Séquençage)

  • Corinne Dumont

    (Genoscope-Centre National de Séquençage)

  • Thomas Guérin

    (Genoscope-Centre National de Séquençage)

  • Sébastien Haffray

    (Genoscope-Centre National de Séquençage)

  • Rachid Hammadi

    (Genoscope-Centre National de Séquençage)

  • Jacqueline Muanga

    (Genoscope-Centre National de Séquençage)

  • Virginie Pellouin

    (Genoscope-Centre National de Séquençage)

  • Dominique Robert

    (Genoscope-Centre National de Séquençage)

  • Edith Wunderle

    (Genoscope-Centre National de Séquençage)

  • Gilbert Gauguet

    (Genoscope-Centre National de Séquençage)

  • Alice Roy

    (Genoscope-Centre National de Séquençage)

  • Laurent Sainte-Marthe

    (Genoscope-Centre National de Séquençage)

  • Jean Verdier

    (Genoscope-Centre National de Séquençage)

  • Claude Verdier-Discala

    (Genoscope-Centre National de Séquençage)

  • LaDeana Hillier

    (Genome Sequencing Center, Washington University School of Medicine)

  • Lucinda Fulton

    (Genome Sequencing Center, Washington University School of Medicine)

  • John McPherson

    (Genome Sequencing Center, Washington University School of Medicine)

  • Fumihiko Matsuda

    (Centre National de Génotypage)

  • Richard Wilson

    (Genome Sequencing Center, Washington University School of Medicine)

  • Claude Scarpelli

    (Genoscope-Centre National de Séquençage)

  • Gábor Gyapay

    (Genoscope-Centre National de Séquençage)

  • Patrick Wincker

    (Genoscope-Centre National de Séquençage)

  • William Saurin

    (Genoscope-Centre National de Séquençage)

  • Francis Quétier

    (Genoscope-Centre National de Séquençage
    UMR-8030, CNRS et Université d'Evry)

  • Robert Waterston

    (Genome Sequencing Center, Washington University School of Medicine)

  • Leroy Hood

    (Institute for Systems Biology)

  • Jean Weissenbach

    (Genoscope-Centre National de Séquençage
    UMR-8030, CNRS et Université d'Evry)

Abstract

Chromosome 14 is one of five acrocentric chromosomes in the human genome. These chromosomes are characterized by a heterochromatic short arm that contains essentially ribosomal RNA genes, and a euchromatic long arm in which most, if not all, of the protein-coding genes are located. The finished sequence of human chromosome 14 comprises 87,410,661 base pairs, representing 100% of its euchromatic portion, in a single continuous segment covering the entire long arm with no gaps. Two loci of crucial importance for the immune system, as well as more than 60 disease genes, have been localized so far on chromosome 14. We identified 1,050 genes and gene fragments, and 393 pseudogenes. On the basis of comparisons with other vertebrate genomes, we estimate that more than 96% of the chromosome 14 genes have been annotated. From an analysis of the CpG island occurrences, we estimate that 70% of these annotated genes are complete at their 5′ end.

Suggested Citation

  • Roland Heilig & Ralph Eckenberg & Jean-Louis Petit & Núria Fonknechten & Corinne Da Silva & Laurence Cattolico & Michaël Levy & Valérie Barbe & Véronique de Berardinis & Abel Ureta-Vidal & Eric Pellet, 2003. "The DNA sequence and analysis of human chromosome 14," Nature, Nature, vol. 421(6923), pages 601-607, February.
    • Handle: RePEc:nat:nature:v:421:y:2003:i:6923:d:10.1038_nature01348
    DOI: 10.1038/nature01348
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