IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v420y2002i6916d10.1038_nature01216.html
   My bibliography  Save this article

Large clusters of co-expressed genes in the Drosophila genome

Author

Listed:
  • Alexander M. Boutanaev

    (Tufts University School of Medicine
    Institute of Molecular Genetics, Russian Academy of Sciences)

  • Alla I. Kalmykova

    (Institute of Molecular Genetics, Russian Academy of Sciences)

  • Yuri Y. Shevelyov

    (Institute of Molecular Genetics, Russian Academy of Sciences)

  • Dmitry I. Nurminsky

    (Tufts University School of Medicine)

Abstract

Clustering of co-expressed, non-homologous genes on chromosomes implies their co-regulation. In lower eukaryotes, co-expressed genes are often found in pairs1,2. Clustering of genes that share aspects of transcriptional regulation has also been reported in higher eukaryotes3,4. To advance our understanding of the mode of coordinated gene regulation in multicellular organisms, we performed a genome-wide analysis of the chromosomal distribution of co-expressed genes in Drosophila. We identified a total of 1,661 testes-specific genes, one-third of which are clustered on chromosomes. The number of clusters of three or more genes is much higher than expected by chance. We observed a similar trend for genes upregulated in the embryo and in the adult head, although the expression pattern of individual genes cannot be predicted on the basis of chromosomal position alone. Our data suggest that the prevalent mechanism of transcriptional co-regulation in higher eukaryotes operates with extensive chromatin domains that comprise multiple genes.

Suggested Citation

  • Alexander M. Boutanaev & Alla I. Kalmykova & Yuri Y. Shevelyov & Dmitry I. Nurminsky, 2002. "Large clusters of co-expressed genes in the Drosophila genome," Nature, Nature, vol. 420(6916), pages 666-669, December.
    • Handle: RePEc:nat:nature:v:420:y:2002:i:6916:d:10.1038_nature01216
    DOI: 10.1038/nature01216
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature01216
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature01216?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Walters, Eli & Altman, Naomi S. & Elnitski, Laura, 2006. "Clustering of gene locations," Computational Statistics & Data Analysis, Elsevier, vol. 50(10), pages 2920-2932, June.
    2. Carlos Díaz-Castillo, 2013. "Females and Males Contribute in Opposite Ways to the Evolution of Gene Order in Drosophila," PLOS ONE, Public Library of Science, vol. 8(5), pages 1-10, May.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:420:y:2002:i:6916:d:10.1038_nature01216. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.