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Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation

Author

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  • Veronika Groh

    (Fred Hutchinson Cancer Research Center, Clinical Research Division)

  • Jennifer Wu

    (Fred Hutchinson Cancer Research Center, Clinical Research Division)

  • Cassian Yee

    (Fred Hutchinson Cancer Research Center, Clinical Research Division)

  • Thomas Spies

    (Fred Hutchinson Cancer Research Center, Clinical Research Division)

Abstract

Engagement of the NKG2D receptor by tumour-associated ligands may promote tumour rejection by stimulating innate and adaptive lymphocyte responses1,2,3,4,5. In humans, NKG2D is expressed on most natural killer cells, γδ T cells and CD8αβ T cells1. Ligands of NKG2D include the major histocompatibility complex class I homologues MICA and MICB, which function as signals of cellular stress6,7. These molecules are absent from most cells and tissues but can be induced by viral and bacterial infections and are frequently expressed in epithelial tumours8,9,10,11. MIC engagement of NKG2D triggers natural killer cells and costimulates antigen-specific effector T cells1,10. Here we show that binding of MIC induces endocytosis and degradation of NKG2D. Expression of NKG2D is reduced markedly on large numbers of tumour-infiltrating and matched peripheral blood T cells from individuals with cancer. This systemic deficiency is associated with circulating tumour-derived soluble MICA, causing the downregulation of NKG2D and in turn severe impairment of the responsiveness of tumour-antigen-specific effector T cells. This mode of T-cell silencing may promote tumour immune evasion and, by inference, compromise host resistance to infections.

Suggested Citation

  • Veronika Groh & Jennifer Wu & Cassian Yee & Thomas Spies, 2002. "Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation," Nature, Nature, vol. 419(6908), pages 734-738, October.
    • Handle: RePEc:nat:nature:v:419:y:2002:i:6908:d:10.1038_nature01112
    DOI: 10.1038/nature01112
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    Cited by:

    1. Guillaume Onyeaghala & John Lane & Nathan Pankratz & Heather H Nelson & Bharat Thyagarajan & Bruce Walcheck & Kristin E Anderson & Anna E Prizment, 2019. "Association between MICA polymorphisms, s-MICA levels, and pancreatic cancer risk in a population-based case-control study," PLOS ONE, Public Library of Science, vol. 14(6), pages 1-13, June.
    2. Davide Bernareggi & Qi Xie & Briana C. Prager & Jiyoung Yun & Luisjesus S. Cruz & Timothy V. Pham & William Kim & Xiqing Lee & Michael Coffey & Cristina Zalfa & Pardis Azmoon & Huang Zhu & Pablo Tamay, 2022. "CHMP2A regulates tumor sensitivity to natural killer cell-mediated cytotoxicity," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    3. Romain Marlin & Marion Duriez & Nadia Berkane & Claire de Truchis & Yoann Madec & Marie-Anne Rey-Cuille & Jean-Saville Cummings & Claude Cannou & Heloise Quillay & Françoise Barré-Sinoussi & Marie-Thé, 2012. "Dynamic Shift from CD85j/ILT-2 to NKG2D NK Receptor Expression Pattern on Human Decidual NK during the First Trimester of Pregnancy," PLOS ONE, Public Library of Science, vol. 7(1), pages 1-9, January.

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