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Directionally selective calcium signals in dendrites of starburst amacrine cells

Author

Listed:
  • Thomas Euler

    (Max Planck Institute for Medical Research)

  • Peter B. Detwiler

    (University of Washington
    Biophysics)

  • Winfried Denk

    (Max Planck Institute for Medical Research)

Abstract

The detection of image motion is fundamental to vision. In many species, unique classes of retinal ganglion cells selectively respond to visual stimuli that move in specific directions. It is not known which retinal cell first performs the neural computations that give rise to directional selectivity in the ganglion cell. A prominent candidate has been an interneuron called the ‘starburst amacrine cell’. Using two-photon optical recordings of intracellular calcium concentration, here we find that individual dendritic branches of starburst cells act as independent computation modules. Dendritic calcium signals, but not somatic membrane voltage, are directionally selective for stimuli that move centrifugally from the cell soma. This demonstrates that direction selectivity is computed locally in dendritic branches at a stage before ganglion cells.

Suggested Citation

  • Thomas Euler & Peter B. Detwiler & Winfried Denk, 2002. "Directionally selective calcium signals in dendrites of starburst amacrine cells," Nature, Nature, vol. 418(6900), pages 845-852, August.
    • Handle: RePEc:nat:nature:v:418:y:2002:i:6900:d:10.1038_nature00931
    DOI: 10.1038/nature00931
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    Cited by:

    1. Sichen Tao & Yuki Todo & Zheng Tang & Bin Li & Zhiming Zhang & Riku Inoue, 2022. "A Novel Artificial Visual System for Motion Direction Detection in Grayscale Images," Mathematics, MDPI, vol. 10(16), pages 1-32, August.
    2. Andrew Jo & Sercan Deniz & Suraj Cherian & Jian Xu & Daiki Futagi & Steven H. DeVries & Yongling Zhu, 2023. "Modular interneuron circuits control motion sensitivity in the mouse retina," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    3. Yuxiao Hua & Yuki Todo & Zheng Tang & Sichen Tao & Bin Li & Riku Inoue, 2022. "A Novel Bio-Inspired Motion Direction Detection Mechanism in Binary and Grayscale Background," Mathematics, MDPI, vol. 10(20), pages 1-16, October.
    4. Xiliang Zhang & Sichen Tao & Zheng Tang & Shuxin Zheng & Yoki Todo, 2023. "The Mechanism of Orientation Detection Based on Artificial Visual System for Greyscale Images," Mathematics, MDPI, vol. 11(12), pages 1-13, June.
    5. Tobias Clark & Vera Hapiak & Mitchell Oakes & Holly Mills & Richard Komuniecki, 2018. "Monoamines differentially modulate neuropeptide release from distinct sites within a single neuron pair," PLOS ONE, Public Library of Science, vol. 13(5), pages 1-22, May.
    6. Andrew Jo & Sercan Deniz & Jian Xu & Robert M. Duvoisin & Steven H. DeVries & Yongling Zhu, 2023. "A sign-inverted receptive field of inhibitory interneurons provides a pathway for ON-OFF interactions in the retina," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    7. Héctor Acarón Ledesma & Jennifer Ding & Swen Oosterboer & Xiaolin Huang & Qiang Chen & Sui Wang & Michael Z. Lin & Wei Wei, 2024. "Dendritic mGluR2 and perisomatic Kv3 signaling regulate dendritic computation of mouse starburst amacrine cells," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    8. Jen-Chun Hsiang & Ning Shen & Florentina Soto & Daniel Kerschensteiner, 2024. "Distributed feature representations of natural stimuli across parallel retinal pathways," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    9. Yeon Jin Kim & Beth B. Peterson & Joanna D. Crook & Hannah R. Joo & Jiajia Wu & Christian Puller & Farrel R. Robinson & Paul D. Gamlin & King-Wai Yau & Felix Viana & John B. Troy & Robert G. Smith & O, 2022. "Origins of direction selectivity in the primate retina," Nature Communications, Nature, vol. 13(1), pages 1-20, December.

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