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Alternative pre-mRNA splicing and proteome expansion in metazoans

Author

Listed:
  • Tom Maniatis

    (Harvard University)

  • Bosiljka Tasic

    (Harvard University)

Abstract

The protein coding sequences of most eukaryotic messenger RNA precursors (pre-mRNAs) are interrupted by non-coding sequences called introns. Pre-mRNA splicing is the process by which introns are removed and the protein coding elements assembled into mature mRNAs. Alternative pre-mRNA splicing selectively joins different protein coding elements to form mRNAs that encode proteins with distinct functions, and is therefore an important source of protein diversity. The elaboration of this mechanism may have had a significant role in the expansion of metazoan proteomes during evolution.

Suggested Citation

  • Tom Maniatis & Bosiljka Tasic, 2002. "Alternative pre-mRNA splicing and proteome expansion in metazoans," Nature, Nature, vol. 418(6894), pages 236-243, July.
    • Handle: RePEc:nat:nature:v:418:y:2002:i:6894:d:10.1038_418236a
    DOI: 10.1038/418236a
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    Cited by:

    1. Jie Cheng & Yamei Yu & Xingyu Wang & Xi Zheng & Ting Liu & Daojun Hu & Yongfeng Jin & Ying Lai & Tian-Min Fu & Qiang Chen, 2023. "Structural basis for the self-recognition of sDSCAM in Chelicerata," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    2. Justin Bo-Kai Hsu & Neil Arvin Bretaña & Tzong-Yi Lee & Hsien-Da Huang, 2011. "Incorporating Evolutionary Information and Functional Domains for Identifying RNA Splicing Factors in Humans," PLOS ONE, Public Library of Science, vol. 6(11), pages 1-11, November.
    3. Uwe Ohler & Noam Shomron & Christopher B Burge, 2005. "Recognition of Unknown Conserved Alternatively Spliced Exons," PLOS Computational Biology, Public Library of Science, vol. 1(2), pages 1-1, July.
    4. André Corvelo & Martina Hallegger & Christopher W J Smith & Eduardo Eyras, 2010. "Genome-Wide Association between Branch Point Properties and Alternative Splicing," PLOS Computational Biology, Public Library of Science, vol. 6(11), pages 1-13, November.

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