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TREX is a conserved complex coupling transcription with messenger RNA export

Author

Listed:
  • Katja Sträßer

    (BZH, University of Heidelberg)

  • Seiji Masuda

    (Harvard Medical School)

  • Paul Mason

    (Harvard Medical School)

  • Jens Pfannstiel

    (BZH, University of Heidelberg)

  • Marisa Oppizzi

    (BZH, University of Heidelberg)

  • Susana Rodriguez-Navarro

    (BZH, University of Heidelberg)

  • Ana G. Rondón

    (University of Sevilla)

  • Andres Aguilera

    (University of Sevilla)

  • Kevin Struhl

    (Harvard Medical School)

  • Robin Reed

    (Harvard Medical School)

  • Ed Hurt

    (BZH, University of Heidelberg)

Abstract

The essential yeast proteins Yra1 and Sub2 are messenger RNA export factors that have conserved counterparts in metazoans, designated Aly and UAP56, respectively1,2,3,4,5,6,7. These factors couple the machineries that function in splicing and export of mRNA1,2,3,4,5,6,7. Here we show that both Yra1 and Sub2 are stoichiometrically associated with the heterotetrameric THO complex8, which functions in transcription in yeast8,9,10,11. We also show that Sub2 and Yra1 interact genetically with all four components of the THO complex (Tho2, Hpr1, Mft1 and Thp2). Moreover, these components operate in the export of bulk poly(A)+ RNA as well as of mRNA derived from intronless genes. Both Aly and UAP56 associate with human counterparts of the THO complex. Together, these data define a conserved complex, designated the TREX (‘transcription/export’) complex. The TREX complex is specifically recruited to activated genes during transcription and travels the entire length of the gene with RNA polymerase II. Our data indicate that the TREX complex has a conserved role in coupling transcription to mRNA export.

Suggested Citation

  • Katja Sträßer & Seiji Masuda & Paul Mason & Jens Pfannstiel & Marisa Oppizzi & Susana Rodriguez-Navarro & Ana G. Rondón & Andres Aguilera & Kevin Struhl & Robin Reed & Ed Hurt, 2002. "TREX is a conserved complex coupling transcription with messenger RNA export," Nature, Nature, vol. 417(6886), pages 304-308, May.
    • Handle: RePEc:nat:nature:v:417:y:2002:i:6886:d:10.1038_nature746
    DOI: 10.1038/nature746
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