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A blue-light-activated adenylyl cyclase mediates photoavoidance in Euglena gracilis

Author

Listed:
  • Mineo Iseki

    (National Institute for Basic Biology
    Bio-oriented Technology Research Advancement Institution, 3-18-19, Toranomon
    Center for Gene Research, Nagoya University, Furo-cho)

  • Shigeru Matsunaga

    (Institute of Biological Sciences, University of Tsukuba)

  • Akio Murakami

    (Kobe University Research Center for Inland Seas)

  • Kaoru Ohno

    (National Institute for Basic Biology)

  • Kiyoshi Shiga

    (Kumamoto University School of Medicine, Honjo)

  • Kazuichi Yoshida

    (National Institute for Basic Biology)

  • Michizo Sugai

    (Faculty of Science, Toyama University)

  • Tetsuo Takahashi

    (School of Pharmaceutical Sciences, Toho University, 2-2-1, Miyama)

  • Terumitsu Hori

    (Institute of Biological Sciences, University of Tsukuba)

  • Masakatsu Watanabe

    (National Institute for Basic Biology
    School of Advanced Sciences, Graduate University for Advanced Studies)

Abstract

Blue light regulates processes such as the development of plants and fungi and the behaviour of microbes1,2. Two types of blue-light receptor flavoprotein have been identified: cryptochromes, which have partial similarity to photolyases3,4, and phototropins, which are photoregulated protein kinases5,6. The former have also been found in animals with evidence of essential roles in circadian rhythms7,8. Euglena gracilis, a unicellular flagellate, abruptly changes its swimming direction after a sudden increase or decrease in incident blue light intensity, that is, step-up or step-down photophobic responses, resulting in photoavoidance or photoaccumulation, respectively9. Although these photobehaviours of Euglena have been studied for a century10, the photoreceptor molecules mediating them have remained unknown9. Here we report the discovery and biochemical characterization of a new type of blue-light receptor flavoprotein, photoactivated adenylyl cyclase, in the photoreceptor organelle of Euglena gracilis, with molecular genetic evidence that it mediates the step-up photophobic response.

Suggested Citation

  • Mineo Iseki & Shigeru Matsunaga & Akio Murakami & Kaoru Ohno & Kiyoshi Shiga & Kazuichi Yoshida & Michizo Sugai & Tetsuo Takahashi & Terumitsu Hori & Masakatsu Watanabe, 2002. "A blue-light-activated adenylyl cyclase mediates photoavoidance in Euglena gracilis," Nature, Nature, vol. 415(6875), pages 1047-1051, February.
    • Handle: RePEc:nat:nature:v:415:y:2002:i:6875:d:10.1038_4151047a
    DOI: 10.1038/4151047a
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    Cited by:

    1. Yalin Zhou & Siwei Tang & Zijing Chen & Zhongneng Zhou & Jiulong Huang & Xiu-Wen Kang & Shuhua Zou & Bingyao Wang & Tianyi Zhang & Bei Ding & Dongping Zhong, 2024. "Origin of the multi-phasic quenching dynamics in the BLUF domains across the species," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    2. Julia Dietler & Renate Gelfert & Jennifer Kaiser & Veniamin Borin & Christian Renzl & Sebastian Pilsl & Américo Tavares Ranzani & Andrés García de Fuentes & Tobias Gleichmann & Ralph P. Diensthuber & , 2022. "Signal transduction in light-oxygen-voltage receptors lacking the active-site glutamine," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

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