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Frizzled-7 signalling controls tissue separation during Xenopus gastrulation

Author

Listed:
  • Rudolf Winklbauer

    (Max-Planck-Institute for Developmental Biology
    University of Toronto)

  • Araceli Medina

    (Max-Planck-Institute for Developmental Biology)

  • Rajeeb K. Swain

    (Max-Planck-Institute for Developmental Biology)

  • Herbert Steinbeisser

Abstract

Cell signalling through Frizzled receptors has evolved to considerable complexity within the metazoans. The Frizzled-dependent signalling cascade comprises several branches, whose differential activation depends on specific Wnt ligands, Frizzled receptor isoforms and the cellular context. In Xenopus laevis embryos, the canonical β-catenin pathway contributes to the establishment of the dorsal–ventral axis1. A different branch, referred to as the planar cell polarity pathway, is essential for cell polarization during elongation of the axial mesoderm by convergent extension2. Here we demonstrate that a third branch of the cascade is independent of Dishevelled function and involves signalling through trimeric G proteins and protein kinase C (PKC). During gastrulation, Frizzled-7 (Fz7)-dependent PKC signalling controls cell-sorting behaviour in the mesoderm. Loss of zygotic Fz7 function results in the inability of involuted anterior mesoderm to separate from the ectoderm, which leads to severe gastrulation defects. This result provides a developmentally relevant in vivo function for the Fz/PKC pathway in vertebrates.

Suggested Citation

  • Rudolf Winklbauer & Araceli Medina & Rajeeb K. Swain & Herbert Steinbeisser, 2001. "Frizzled-7 signalling controls tissue separation during Xenopus gastrulation," Nature, Nature, vol. 413(6858), pages 856-860, October.
  • Handle: RePEc:nat:nature:v:413:y:2001:i:6858:d:10.1038_35101621
    DOI: 10.1038/35101621
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