IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v413y2001i6854d10.1038_35096643.html
   My bibliography  Save this article

Receptor-specific messenger oscillations

Author

Listed:
  • Mark S. Nash

    (Medical Sciences Building, University of Leicester)

  • Kenneth W. Young

    (Medical Sciences Building, University of Leicester)

  • R. A. John Challiss

    (Medical Sciences Building, University of Leicester)

  • Stefan R. Nahorski

    (Medical Sciences Building, University of Leicester)

Abstract

The cytosolic molecule inositol-1,4,5-trisphosphate (InsP3) acts as a messenger to link receptors at the cell surface with alterations in calcium concentration inside the cell1, but it is not clear how production of InsP3 is related to the often-complex calcium response2. Here we use a fluorescent biosensor to visualize InsP3 synthesis in individual cells in real time and show that this is periodically switched on and off in a receptor-specific manner. Our findings are consistent with intracellular calcium oscillations being generated by either fluctuating or sustained concentrations of InsP3, which may allow diversity of signalling through the same signal-transduction pathway.

Suggested Citation

  • Mark S. Nash & Kenneth W. Young & R. A. John Challiss & Stefan R. Nahorski, 2001. "Receptor-specific messenger oscillations," Nature, Nature, vol. 413(6854), pages 381-382, September.
  • Handle: RePEc:nat:nature:v:413:y:2001:i:6854:d:10.1038_35096643
    DOI: 10.1038/35096643
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/35096643
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.

    File URL: https://libkey.io/10.1038/35096643?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:413:y:2001:i:6854:d:10.1038_35096643. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.