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Incubation of cocaine craving after withdrawal

Author

Listed:
  • Jeffrey W. Grimm

    (Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health)

  • Bruce T. Hope

    (Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health)

  • Roy A. Wise

    (Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health)

  • Yavin Shaham

    (Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health)

Abstract

Relapse to cocaine addiction is frequently associated with subjective reports of craving, a poorly understood state that precedes and accompanies cocaine-seeking behaviours1. It has been suggested2 that over the first few weeks of withdrawal from cocaine, human addicts become sensitized to drug-associated environmental cues that act as external stimuli for craving, although the evidence for this is inconsistent3. Here we provide behavioural evidence from laboratory animals suggesting that the onset of craving is delayed and that craving does not decay, but rather increases progressively, over a two-month withdrawal period.

Suggested Citation

  • Jeffrey W. Grimm & Bruce T. Hope & Roy A. Wise & Yavin Shaham, 2001. "Incubation of cocaine craving after withdrawal," Nature, Nature, vol. 412(6843), pages 141-142, July.
    • Handle: RePEc:nat:nature:v:412:y:2001:i:6843:d:10.1038_35084134
    DOI: 10.1038/35084134
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    Cited by:

    1. C. Nicolas & A. Ju & Y. Wu & H. Eldirdiri & S. Delcasso & Y. Couderc & C. Fornari & A. Mitra & L. Supiot & A. Vérité & M. Masson & S. Rodriguez-Rozada & D. Jacky & J. S. Wiegert & A. Beyeler, 2023. "Linking emotional valence and anxiety in a mouse insula-amygdala circuit," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    2. Qiang Li & Yarong Wang & Yi Zhang & Wei Li & Jia Zhu & Ying Zheng & Jiajie Chen & Liyan Zhao & Zhenyu Zhou & Yijun Liu & Wei Wang & Jie Tian, 2013. "Assessing Cue-Induced Brain Response as a Function of Abstinence Duration in Heroin-Dependent Individuals: An Event-Related fMRI Study," PLOS ONE, Public Library of Science, vol. 8(5), pages 1-8, May.

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