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Subcellular positioning of small molecules

Author

Listed:
  • Shuichi Takayama

    (Harvard University
    University of Michigan)

  • Emanuele Ostuni

    (Harvard University
    Surface Logix Inc.)

  • Philip LeDuc

    (Children's Hospital and Harvard Medical School)

  • Keiji Naruse

    (Children's Hospital and Harvard Medical School
    Nagoya University School of Medicine)

  • Donald E. Ingber

    (University of Michigan)

  • George M. Whitesides

    (Harvard University)

Abstract

Localized perturbation of processes that take place inside the living cell depends on molecular and spatial discrimination on a micrometre scale. Here we report the use of multiple laminar streams in a microfluidic channel to deliver membrane-permeable molecules to selected subcellular microdomains. This technique opens up avenues for non-invasively visualizing, probing and manipulating the cellular metabolic and structural machinery.

Suggested Citation

  • Shuichi Takayama & Emanuele Ostuni & Philip LeDuc & Keiji Naruse & Donald E. Ingber & George M. Whitesides, 2001. "Subcellular positioning of small molecules," Nature, Nature, vol. 411(6841), pages 1016-1016, June.
    • Handle: RePEc:nat:nature:v:411:y:2001:i:6841:d:10.1038_35082637
    DOI: 10.1038/35082637
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