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The status of Wnt signalling regulates neural and epidermal fates in the chick embryo

Author

Listed:
  • Sara Wilson

    (Umeå University)

  • Anna Rydström

    (Umeå University)

  • Tolleiv Trimborn

    (Howard Hughes Medical Institute, Stanford University, School of Medicine, Beckman Center)

  • Karl Willert

    (Howard Hughes Medical Institute, Stanford University, School of Medicine, Beckman Center)

  • Roel Nusse

    (Howard Hughes Medical Institute, Stanford University, School of Medicine, Beckman Center)

  • Thomas M. Jessell

    (Howard Hughes Medical Institute, Dept. of Biochemistry and Molecular Biophysics, Columbia University)

  • Thomas Edlund

    (Umeå University)

Abstract

The acquisition of neural fate by embryonic ectodermal cells is a fundamental step in the formation of the vertebrate nervous system. Neural induction seems to involve signalling by fibroblast growth factors (FGFs) and attenuation of the activity of bone morphogenetic protein (BMP)1,2,3,4. But FGFs, either alone or in combination with BMP antagonists, are not sufficient to induce neural fate in prospective epidermal ectoderm of amniote embryos1,3,4. These findings suggest that additional signals are involved in the specification of neural fate. Here we show that the state of Wnt signalling is a critical determinant of neural and epidermal fates in the chick embryo. Continual Wnt signalling blocks the response of epiblast cells to FGF signals, permitting the expression and signalling of BMP to direct an epidermal fate. Conversely, a lack of exposure of epiblast cells to Wnt signals permits FGFs to induce a neural fate.

Suggested Citation

  • Sara Wilson & Anna Rydström & Tolleiv Trimborn & Karl Willert & Roel Nusse & Thomas M. Jessell & Thomas Edlund, 2001. "The status of Wnt signalling regulates neural and epidermal fates in the chick embryo," Nature, Nature, vol. 411(6835), pages 325-330, May.
    • Handle: RePEc:nat:nature:v:411:y:2001:i:6835:d:10.1038_35077115
    DOI: 10.1038/35077115
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